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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: X-66599555-C-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=66599555&ref=C&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "X",
      "pos": 66599555,
      "ref": "C",
      "alt": "G",
      "effect": "missense_variant",
      "transcript": "NM_001242310.1",
      "consequences": [
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.823G>C",
          "hgvs_p": "p.Gly275Arg",
          "transcript": "NM_021783.5",
          "protein_id": "NP_068555.2",
          "transcript_support_level": null,
          "aa_start": 275,
          "aa_end": null,
          "aa_length": 297,
          "cds_start": 823,
          "cds_end": null,
          "cds_length": 894,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000374719.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_021783.5"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.823G>C",
          "hgvs_p": "p.Gly275Arg",
          "transcript": "ENST00000374719.8",
          "protein_id": "ENSP00000363851.3",
          "transcript_support_level": 1,
          "aa_start": 275,
          "aa_end": null,
          "aa_length": 297,
          "cds_start": 823,
          "cds_end": null,
          "cds_length": 894,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_021783.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000374719.8"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.886G>C",
          "hgvs_p": "p.Gly296Arg",
          "transcript": "ENST00000253392.5",
          "protein_id": "ENSP00000253392.5",
          "transcript_support_level": 1,
          "aa_start": 296,
          "aa_end": null,
          "aa_length": 318,
          "cds_start": 886,
          "cds_end": null,
          "cds_length": 957,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000253392.5"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.886G>C",
          "hgvs_p": "p.Gly296Arg",
          "transcript": "NM_001242310.1",
          "protein_id": "NP_001229239.1",
          "transcript_support_level": null,
          "aa_start": 296,
          "aa_end": null,
          "aa_length": 318,
          "cds_start": 886,
          "cds_end": null,
          "cds_length": 957,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001242310.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.886G>C",
          "hgvs_p": "p.Gly296Arg",
          "transcript": "ENST00000396050.5",
          "protein_id": "ENSP00000379365.2",
          "transcript_support_level": 5,
          "aa_start": 296,
          "aa_end": null,
          "aa_length": 318,
          "cds_start": 886,
          "cds_end": null,
          "cds_length": 957,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000396050.5"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.829G>C",
          "hgvs_p": "p.Gly277Arg",
          "transcript": "NM_001324206.2",
          "protein_id": "NP_001311135.2",
          "transcript_support_level": null,
          "aa_start": 277,
          "aa_end": null,
          "aa_length": 299,
          "cds_start": 829,
          "cds_end": null,
          "cds_length": 900,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001324206.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.829G>C",
          "hgvs_p": "p.Gly277Arg",
          "transcript": "ENST00000902730.1",
          "protein_id": "ENSP00000572789.1",
          "transcript_support_level": null,
          "aa_start": 277,
          "aa_end": null,
          "aa_length": 299,
          "cds_start": 829,
          "cds_end": null,
          "cds_length": 900,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000902730.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.829G>C",
          "hgvs_p": "p.Gly277Arg",
          "transcript": "ENST00000902732.1",
          "protein_id": "ENSP00000572791.1",
          "transcript_support_level": null,
          "aa_start": 277,
          "aa_end": null,
          "aa_length": 299,
          "cds_start": 829,
          "cds_end": null,
          "cds_length": 900,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000902732.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.829G>C",
          "hgvs_p": "p.Gly277Arg",
          "transcript": "ENST00000944244.1",
          "protein_id": "ENSP00000614303.1",
          "transcript_support_level": null,
          "aa_start": 277,
          "aa_end": null,
          "aa_length": 299,
          "cds_start": 829,
          "cds_end": null,
          "cds_length": 900,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000944244.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.823G>C",
          "hgvs_p": "p.Gly275Arg",
          "transcript": "NM_001199687.3",
          "protein_id": "NP_001186616.2",
          "transcript_support_level": null,
          "aa_start": 275,
          "aa_end": null,
          "aa_length": 297,
          "cds_start": 823,
          "cds_end": null,
          "cds_length": 894,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001199687.3"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.823G>C",
          "hgvs_p": "p.Gly275Arg",
          "transcript": "ENST00000451436.6",
          "protein_id": "ENSP00000415242.3",
          "transcript_support_level": 5,
          "aa_start": 275,
          "aa_end": null,
          "aa_length": 297,
          "cds_start": 823,
          "cds_end": null,
          "cds_length": 894,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000451436.6"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.823G>C",
          "hgvs_p": "p.Gly275Arg",
          "transcript": "ENST00000902731.1",
          "protein_id": "ENSP00000572790.1",
          "transcript_support_level": null,
          "aa_start": 275,
          "aa_end": null,
          "aa_length": 297,
          "cds_start": 823,
          "cds_end": null,
          "cds_length": 894,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000902731.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.727G>C",
          "hgvs_p": "p.Gly243Arg",
          "transcript": "NM_001324201.2",
          "protein_id": "NP_001311130.2",
          "transcript_support_level": null,
          "aa_start": 243,
          "aa_end": null,
          "aa_length": 265,
          "cds_start": 727,
          "cds_end": null,
          "cds_length": 798,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001324201.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.652G>C",
          "hgvs_p": "p.Gly218Arg",
          "transcript": "ENST00000902729.1",
          "protein_id": "ENSP00000572788.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 240,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 723,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000902729.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.652G>C",
          "hgvs_p": "p.Gly218Arg",
          "transcript": "ENST00000944243.1",
          "protein_id": "ENSP00000614302.1",
          "transcript_support_level": null,
          "aa_start": 218,
          "aa_end": null,
          "aa_length": 240,
          "cds_start": 652,
          "cds_end": null,
          "cds_length": 723,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000944243.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.646G>C",
          "hgvs_p": "p.Gly216Arg",
          "transcript": "ENST00000902728.1",
          "protein_id": "ENSP00000572787.1",
          "transcript_support_level": null,
          "aa_start": 216,
          "aa_end": null,
          "aa_length": 238,
          "cds_start": 646,
          "cds_end": null,
          "cds_length": 717,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000902728.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.646G>C",
          "hgvs_p": "p.Gly216Arg",
          "transcript": "ENST00000925064.1",
          "protein_id": "ENSP00000595123.1",
          "transcript_support_level": null,
          "aa_start": 216,
          "aa_end": null,
          "aa_length": 238,
          "cds_start": 646,
          "cds_end": null,
          "cds_length": 717,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000925064.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.451G>C",
          "hgvs_p": "p.Gly151Arg",
          "transcript": "NM_001324199.2",
          "protein_id": "NP_001311128.2",
          "transcript_support_level": null,
          "aa_start": 151,
          "aa_end": null,
          "aa_length": 173,
          "cds_start": 451,
          "cds_end": null,
          "cds_length": 522,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001324199.2"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.925G>C",
          "hgvs_p": "p.Gly309Arg",
          "transcript": "XM_047442294.1",
          "protein_id": "XP_047298250.1",
          "transcript_support_level": null,
          "aa_start": 309,
          "aa_end": null,
          "aa_length": 331,
          "cds_start": 925,
          "cds_end": null,
          "cds_length": 996,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047442294.1"
        },
        {
          "aa_ref": "G",
          "aa_alt": "R",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 8,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.925G>C",
          "hgvs_p": "p.Gly309Arg",
          "transcript": "XM_047442295.1",
          "protein_id": "XP_047298251.1",
          "transcript_support_level": null,
          "aa_start": 309,
          "aa_end": null,
          "aa_length": 331,
          "cds_start": 925,
          "cds_end": null,
          "cds_length": 996,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "n.826G>C",
          "hgvs_p": null,
          "transcript": "NR_136727.2",
          "protein_id": null,
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "NR_136727.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "downstream_gene_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "EDA2R",
          "gene_hgnc_id": 17756,
          "hgvs_c": "c.*304G>C",
          "hgvs_p": null,
          "transcript": "XM_047442314.1",
          "protein_id": "XP_047298270.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 204,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 615,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047442314.1"
        }
      ],
      "gene_symbol": "EDA2R",
      "gene_hgnc_id": 17756,
      "dbsnp": "rs201070562",
      "frequency_reference_population": 0.000023565255,
      "hom_count_reference_population": 10,
      "allele_count_reference_population": 28,
      "gnomad_exomes_af": 0.0000204262,
      "gnomad_genomes_af": 0.0000539845,
      "gnomad_exomes_ac": 22,
      "gnomad_genomes_ac": 6,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.04923316836357117,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.211,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0731,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.63,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.491,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -10,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Moderate,BS2",
      "acmg_by_gene": [
        {
          "score": -10,
          "benign_score": 10,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Strong",
            "BP6_Moderate",
            "BS2"
          ],
          "verdict": "Benign",
          "transcript": "NM_001242310.1",
          "gene_symbol": "EDA2R",
          "hgnc_id": 17756,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "XL",
          "hgvs_c": "c.886G>C",
          "hgvs_p": "p.Gly296Arg"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}