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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: X-71154354-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=X&pos=71154354&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "X",
"pos": 71154354,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000685718.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.577+818A>T",
"hgvs_p": null,
"transcript": "NM_181303.2",
"protein_id": "NP_851820.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 848,
"cds_start": -4,
"cds_end": null,
"cds_length": 2547,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3975,
"mane_select": "ENST00000358741.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.577+818A>T",
"hgvs_p": null,
"transcript": "ENST00000358741.4",
"protein_id": "ENSP00000351591.4",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 848,
"cds_start": -4,
"cds_end": null,
"cds_length": 2547,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3975,
"mane_select": "NM_181303.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.517+818A>T",
"hgvs_p": null,
"transcript": "ENST00000374051.7",
"protein_id": "ENSP00000363163.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 828,
"cds_start": -4,
"cds_end": null,
"cds_length": 2487,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3913,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.458-860A>T",
"hgvs_p": null,
"transcript": "ENST00000395855.7",
"protein_id": "ENSP00000379196.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 528,
"cds_start": -4,
"cds_end": null,
"cds_length": 1587,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2842,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "n.756+818A>T",
"hgvs_p": null,
"transcript": "ENST00000476589.2",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3789,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "n.517+818A>T",
"hgvs_p": null,
"transcript": "ENST00000685718.1",
"protein_id": "ENSP00000510514.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4125,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.517+818A>T",
"hgvs_p": null,
"transcript": "NM_018977.4",
"protein_id": "NP_061850.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 828,
"cds_start": -4,
"cds_end": null,
"cds_length": 2487,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3915,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.458-860A>T",
"hgvs_p": null,
"transcript": "NM_001166660.2",
"protein_id": "NP_001160132.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 808,
"cds_start": -4,
"cds_end": null,
"cds_length": 2427,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3855,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.458-860A>T",
"hgvs_p": null,
"transcript": "ENST00000536169.6",
"protein_id": "ENSP00000445298.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 808,
"cds_start": -4,
"cds_end": null,
"cds_length": 2427,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3812,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 4,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.577+818A>T",
"hgvs_p": null,
"transcript": "ENST00000687470.1",
"protein_id": "ENSP00000508881.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 793,
"cds_start": -4,
"cds_end": null,
"cds_length": 2382,
"cdna_start": null,
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"cdna_length": 6361,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.457+6148A>T",
"hgvs_p": null,
"transcript": "ENST00000689857.1",
"protein_id": "ENSP00000510719.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
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"gene_symbol": "NLGN3",
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"hgvs_c": "c.517+818A>T",
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"transcript": "ENST00000689968.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
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"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.226+818A>T",
"hgvs_p": null,
"transcript": "NM_001437941.1",
"protein_id": "NP_001424870.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "NLGN3",
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"hgvs_c": "c.226+818A>T",
"hgvs_p": null,
"transcript": "NM_001438296.1",
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},
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],
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"transcript": "ENST00000687220.1",
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},
{
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"strand": true,
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],
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"intron_rank": 4,
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"gene_symbol": "NLGN3",
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"hgvs_c": "c.226+818A>T",
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"transcript": "ENST00000688566.1",
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},
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"gene_symbol": "NLGN3",
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"hgvs_c": "c.166+818A>T",
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"transcript": "NM_001321276.2",
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},
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"strand": true,
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],
"exon_rank": null,
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"intron_rank": 4,
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"gene_symbol": "NLGN3",
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"hgvs_c": "c.166+818A>T",
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"transcript": "NM_001438298.1",
"protein_id": "NP_001425227.1",
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},
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 4,
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"gene_symbol": "NLGN3",
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"hgvs_c": "c.166+818A>T",
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"transcript": "ENST00000690133.1",
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],
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],
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"gene_symbol": "NLGN3",
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},
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"consequences": [
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],
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"exon_count": 5,
"intron_rank": 2,
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"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "c.458-860A>T",
"hgvs_p": null,
"transcript": "ENST00000687568.1",
"protein_id": "ENSP00000509635.1",
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "NLGN3",
"gene_hgnc_id": 14289,
"hgvs_c": "n.1560+818A>T",
"hgvs_p": null,
"transcript": "ENST00000688950.1",
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},
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}