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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: Y-14608133-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=Y&pos=14608133&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "Y",
"pos": 14608133,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000684976.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "NM_001365588.1",
"protein_id": "NP_001352517.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 836,
"cds_start": -4,
"cds_end": null,
"cds_length": 2511,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7194,
"mane_select": "ENST00000684976.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "ENST00000684976.1",
"protein_id": "ENSP00000510011.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 836,
"cds_start": -4,
"cds_end": null,
"cds_length": 2511,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7194,
"mane_select": "NM_001365588.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-99-13888T>C",
"hgvs_p": null,
"transcript": "ENST00000382868.5",
"protein_id": "ENSP00000372320.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 873,
"cds_start": -4,
"cds_end": null,
"cds_length": 2622,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5338,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "ENST00000339174.9",
"protein_id": "ENSP00000342535.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 816,
"cds_start": -4,
"cds_end": null,
"cds_length": 2451,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5310,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-99-13888T>C",
"hgvs_p": null,
"transcript": "ENST00000355905.6",
"protein_id": "ENSP00000348169.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 816,
"cds_start": -4,
"cds_end": null,
"cds_length": 2451,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5167,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-93+85192T>C",
"hgvs_p": null,
"transcript": "ENST00000382872.5",
"protein_id": "ENSP00000372325.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 648,
"cds_start": -4,
"cds_end": null,
"cds_length": 1947,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6617,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "n.154-13888T>C",
"hgvs_p": null,
"transcript": "ENST00000476359.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 5460,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "NM_001365584.1",
"protein_id": "NP_001352513.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 836,
"cds_start": -4,
"cds_end": null,
"cds_length": 2511,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7422,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "NM_001365586.1",
"protein_id": "NP_001352515.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 836,
"cds_start": -4,
"cds_end": null,
"cds_length": 2511,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7340,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "NM_001394830.1",
"protein_id": "NP_001381759.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 836,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "NLGN4Y",
"gene_hgnc_id": 15529,
"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "ENST00000643089.1",
"protein_id": "ENSP00000496594.1",
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},
{
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],
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"exon_count": 8,
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-111-13876T>C",
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"transcript": "NM_001365590.1",
"protein_id": "NP_001352519.1",
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},
{
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],
"exon_rank": null,
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"exon_count": 6,
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-111-13876T>C",
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"transcript": "NM_001365591.1",
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},
{
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],
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-111-13876T>C",
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},
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],
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"transcript": "NM_001365593.1",
"protein_id": "NP_001352522.1",
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},
{
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],
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-111-13876T>C",
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"transcript": "NM_001394831.1",
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},
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],
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-99-13888T>C",
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},
{
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],
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-93+85192T>C",
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"transcript": "NM_001206850.2",
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},
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],
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-111-13876T>C",
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},
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],
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},
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],
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},
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],
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"intron_rank": 1,
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-111-13876T>C",
"hgvs_p": null,
"transcript": "XM_006724874.3",
"protein_id": "XP_006724937.1",
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "NLGN4Y",
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"hgvs_c": "c.-111-13876T>C",
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"transcript": "XM_011531427.3",
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}