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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: Y-19731995-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=Y&pos=19731995&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "Y",
"pos": 19731995,
"ref": "A",
"alt": "C",
"effect": "intron_variant",
"transcript": "NM_001146705.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "NM_004653.5",
"protein_id": "NP_004644.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1539,
"cds_start": null,
"cds_end": null,
"cds_length": 4620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000317961.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004653.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "ENST00000317961.9",
"protein_id": "ENSP00000322408.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1539,
"cds_start": null,
"cds_end": null,
"cds_length": 4620,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004653.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000317961.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "ENST00000541639.5",
"protein_id": "ENSP00000444293.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1570,
"cds_start": null,
"cds_end": null,
"cds_length": 4713,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000541639.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1041+51T>G",
"hgvs_p": null,
"transcript": "ENST00000382806.6",
"protein_id": "ENSP00000372256.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1482,
"cds_start": null,
"cds_end": null,
"cds_length": 4449,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000382806.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1230+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893732.1",
"protein_id": "ENSP00000563791.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1576,
"cds_start": null,
"cds_end": null,
"cds_length": 4731,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893732.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "NM_001146705.2",
"protein_id": "NP_001140177.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1570,
"cds_start": null,
"cds_end": null,
"cds_length": 4713,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001146705.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1230+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893734.1",
"protein_id": "ENSP00000563793.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1545,
"cds_start": null,
"cds_end": null,
"cds_length": 4638,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893734.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "ENST00000944747.1",
"protein_id": "ENSP00000614806.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1538,
"cds_start": null,
"cds_end": null,
"cds_length": 4617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944747.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1173+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893729.1",
"protein_id": "ENSP00000563788.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1526,
"cds_start": null,
"cds_end": null,
"cds_length": 4581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893729.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1095+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893730.1",
"protein_id": "ENSP00000563789.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1500,
"cds_start": null,
"cds_end": null,
"cds_length": 4503,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893730.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "ENST00000944746.1",
"protein_id": "ENSP00000614805.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1493,
"cds_start": null,
"cds_end": null,
"cds_length": 4482,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000944746.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1041+51T>G",
"hgvs_p": null,
"transcript": "NM_001146706.2",
"protein_id": "NP_001140178.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1482,
"cds_start": null,
"cds_end": null,
"cds_length": 4449,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001146706.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1038+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893728.1",
"protein_id": "ENSP00000563787.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1481,
"cds_start": null,
"cds_end": null,
"cds_length": 4446,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893728.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1089+51T>G",
"hgvs_p": null,
"transcript": "ENST00000440077.5",
"protein_id": "ENSP00000398543.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1475,
"cds_start": null,
"cds_end": null,
"cds_length": 4429,
"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000440077.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893727.1",
"protein_id": "ENSP00000563786.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1474,
"cds_start": null,
"cds_end": null,
"cds_length": 4425,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893727.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.906+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893733.1",
"protein_id": "ENSP00000563792.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1468,
"cds_start": null,
"cds_end": null,
"cds_length": 4407,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893733.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1212+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893725.1",
"protein_id": "ENSP00000563784.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1462,
"cds_start": null,
"cds_end": null,
"cds_length": 4389,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893725.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 10,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1173+51T>G",
"hgvs_p": null,
"transcript": "ENST00000933680.1",
"protein_id": "ENSP00000603739.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1449,
"cds_start": null,
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"cds_length": 4350,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933680.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.906+51T>G",
"hgvs_p": null,
"transcript": "ENST00000933679.1",
"protein_id": "ENSP00000603738.1",
"transcript_support_level": null,
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"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933679.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1089+51T>G",
"hgvs_p": null,
"transcript": "ENST00000893726.1",
"protein_id": "ENSP00000563785.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000893726.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1041+51T>G",
"hgvs_p": null,
"transcript": "ENST00000933681.1",
"protein_id": "ENSP00000603740.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1405,
"cds_start": null,
"cds_end": null,
"cds_length": 4218,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933681.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "KDM5D",
"gene_hgnc_id": 11115,
"hgvs_c": "c.1002+51T>G",
"hgvs_p": null,
"transcript": "ENST00000933682.1",
"protein_id": "ENSP00000603741.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1392,
"cds_start": null,
"cds_end": null,
"cds_length": 4179,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933682.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
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