ADGRE4P

adhesion G protein-coupled receptor E4, pseudogene, the group of Adhesion G protein-coupled receptors, subfamily E

Basic information

Region (hg38): 19:6954659-6990798

Previous symbols: [ "GPR127", "EMR4", "EMR4P" ]

Links

ENSG00000268758

∙ NCBI:326342 ∙ OMIM:612305 ∙ HGNC:19240 ∙ Uniprot:Q86SQ3 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ADGRE4P gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ADGRE4P gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Function: FUNCTION: May mediate the cellular interaction between myeloid cells and B-cells. {ECO:0000250|UniProtKB:Q91ZE5}.;

Haploinsufficiency Scores

pHI: 0.0442
hipred
hipred_score
ghis

Mouse Genome Informatics

Gene name: Adgre4
Phenotype

Gene ontology

Biological process: cell surface receptor signaling pathway;G protein-coupled receptor signaling pathway;adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cellular component: extracellular region;integral component of plasma membrane;integral component of membrane
Molecular function: G protein-coupled receptor activity;calcium ion binding