ADGRF1

protein-coding

adhesion G protein-coupled receptor F1, the group of Adhesion G protein-coupled receptors, subfamily F

Gene summary

Enables G protein-coupled receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

GPR110

MANE transcript

NM_153840.4

Inheritance

—

ClinVar variants

U:141B:17

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.93

Max pathogenic AF

—

Genomic locus

chr6:46,997,708-47,042,350

External References & Databases

Ensembl (ENSG00000153292)

Transcript & Mutation Effects

hg38 • Region Span ~44.6 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ADGRF1 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 143

not providedTotal: 3

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_153840.4. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			2 clinvar			2
missense			134 clinvar	16 clinvar	1 clinvar	151
nonsense			1 clinvar			1
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			4 clinvar			4
Total	0	0	141	16	1	158

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 15 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_153840.4	RefSeq	NP_722582.2	14	MANE Select
ENST00000371253.7	Ensembl	ENSP00000360299.2	14	MANE Select
NM_025048.4	RefSeq	NP_079324.2	7	Standard
ENST00000283297.5	Ensembl	ENSP00000283297.5	9	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway
synapse assembly
memory

Molecular Function

G protein-coupled receptor activity

Cellular Component

extracellular region
plasma membrane
integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000371253
Coding exons: 14
Length: 44660
Individuals with no LoFs: 125596
Homozygous LoFs: 0
Heterozygous LoFs: 152
Defined: 125748
p: 0.000605

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-0.319	503	483	1.04	0.0000247	5942
Missense (PolyPhen)		139	147.57	0.9419		1916
Synonymous	-1.71	222	192	1.16	0.0000104	1808
Loss of Function	0.427	35	37.8	0.925	0.00000175	471

Population LoF Frequency

Population	CAF	p-value	Status
African	0.00074	0.00074	rare
Latino/Admixed American	0.00065	0.00064	rare
Ashkenazi Jewish	0.00020	0.00020	rare
East Asian	0.00093	0.00092	rare
Finnish	0.000092	0.000092	rare
European (Non-Finnish)	0.00062	0.00061	rare
South Asian	0.00086	0.00085	rare
Other	0.00033	0.00033	rare

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Orphan receptor.;

Intolerance Scores

RVIS EVS: 0.7
RVIS percentile EVS: 85.3

Essentials

Essential (gene trap): N