ADGRF3

protein-coding

adhesion G protein-coupled receptor F3, the group of Adhesion G protein-coupled receptors, subfamily F

Gene summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Previous symbols:

GPR113

MANE transcript

NM_001321971.2

Inheritance

—

ClinVar variants

U:153B:20

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.87

Max pathogenic AF

—

Genomic locus

chr2:26,308,173-26,346,817

External References & Databases

Ensembl (ENSG00000173567)

Transcript & Mutation Effects

hg38 • Region Span ~38.6 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ADGRF3 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 182

not providedTotal: 5

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001321971.2. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			3 clinvar	2 clinvar		5
missense			147 clinvar	17 clinvar		164
nonsense			2 clinvar		1 clinvar	3
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	0	153	19	1	173

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 21 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001321971.2	RefSeq	NP_001308900.1	14	MANE Select
ENST00000651242.2	Ensembl	ENSP00000498434.1	14	MANE Select
NM_001145168.1	RefSeq	NP_001138640.1	13	Standard
NM_001145169.1	RefSeq	NP_001138641.1	13	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway

Molecular Function

G protein-coupled receptor activity

Cellular Component

integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000311519
Coding exons: 13
Length: 38645
Individuals with no LoFs: 124642
Homozygous LoFs: 4
Heterozygous LoFs: 947
Defined: 125593
p: 0.00379

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.636	543	586	0.926	0.0000313	6841
Missense (PolyPhen)		151	160.91	0.93839		2144
Synonymous	-0.261	266	261	1.02	0.0000149	2353
Loss of Function	0.792	37	42.6	0.869	0.00000221	440

Population LoF Frequency

Population	CAF	p-value	Status
African	0.0027	0.0025	notable
Latino/Admixed American	0.0016	0.0015	notable
Ashkenazi Jewish	0	0.0	absent
East Asian	0.0027	0.0027	notable
Finnish	0.0013	0.0012	notable
European (Non-Finnish)	0.0070	0.0064	notable
South Asian	0.0011	0.0011	notable
Other	0.0040	0.0038	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Orphan receptor.;

Recessive Scores

pRec: 0.0859

Intolerance Scores

RVIS EVS: 3.57
RVIS percentile EVS: 99.52

Essentials

Essential (gene trap): N