ADGRG7

protein-coding

adhesion G protein-coupled receptor G7, the group of Adhesion G protein-coupled receptors, subfamily G

Gene summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

GPR128

MANE transcript

NM_032787.3

Inheritance

—

ClinVar variants

U:119B:17

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.83

Max pathogenic AF

—

Genomic locus

chr3:100,609,601-100,695,479

External References & Databases

Ensembl (ENSG00000144820)

Transcript & Mutation Effects

hg38 • Region Span ~85.9 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to ADGRG7 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 130

not providedTotal: 8

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_032787.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				1 clinvar	2 clinvar	3
missense			117 clinvar	13 clinvar	1 clinvar	131
nonsense						0
start loss						0
frameshift			1 clinvar			1
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	0	119	14	3	136

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 9 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_032787.3	RefSeq	NP_116176.2	16	MANE Select
ENST00000273352.8	Ensembl	ENSP00000273352.3	16	MANE Select
NM_001308362.1	RefSeq	NP_001295291.1	9	Standard
ENST00000475887.1	Ensembl	ENSP00000419788.1	9	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
adenylate cyclase-activating G protein-coupled receptor signaling pathway

Molecular Function

G protein-coupled receptor activity
protein binding

Cellular Component

integral component of plasma membrane
integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000273352
Coding exons: 16
Length: 85891
Individuals with no LoFs: 125535
Homozygous LoFs: 1
Heterozygous LoFs: 212
Defined: 125748
p: 0.000847

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.377	401	423	0.948	0.0000217	5203
Missense (PolyPhen)		104	121.1	0.85882		1686
Synonymous	-0.832	171	158	1.08	0.00000832	1552
Loss of Function	0.962	30	36.3	0.828	0.00000172	451

Population LoF Frequency

Population	CAF	p-value	Status
African	0.00043	0.00043	rare
Latino/Admixed American	0.0022	0.0022	notable
Ashkenazi Jewish	0	0.0	absent
East Asian	0.000054	0.000054	rare
Finnish	0	0.0	absent
European (Non-Finnish)	0.00078	0.00077	rare
South Asian	0.0011	0.0010	notable
Other	0.0018	0.0018	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Orphan receptor.;

Recessive Scores

pRec: 0.0655

Intolerance Scores

RVIS EVS: 0.81
RVIS percentile EVS: 87.73

Essentials

Essential (gene trap): N