CCL15-CCL14

CCL15-CCL14 readthrough (NMD candidate)

Basic information

Region (hg38): 17:35983655-36001621

Links

ENSG00000275688 ∙ NCBI:348249 ∙ ∙ HGNC:44436 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the CCL15-CCL14 gene.

• Inborn genetic diseases (8 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the CCL15-CCL14 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			7	1		8
Total	0	0	7	1	0

Variants in CCL15-CCL14

This is a list of pathogenic ClinVar variants found in the CCL15-CCL14 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
17-35984345-C-T		not specified	Uncertain significance (Jan 06, 2023)
17-35984356-C-T		not specified	Uncertain significance (Dec 05, 2023)
17-35984449-C-T		not specified	Uncertain significance (Jun 24, 2022)
17-35986637-C-T		not specified	Likely benign (Oct 13, 2023)
17-35997771-A-G		not specified	Uncertain significance (Jun 24, 2022)
17-35997772-T-C		not specified	Uncertain significance (Dec 15, 2022)
17-35997793-T-G		not specified	Uncertain significance (Nov 08, 2022)
17-35997840-C-T		not specified	Likely benign (Jun 30, 2022)
17-35997841-G-A		not specified	Uncertain significance (Jun 29, 2022)
17-35998325-T-C		not specified	Uncertain significance (Nov 23, 2021)
17-35998904-A-G		not specified	Uncertain significance (Jul 06, 2021)
17-36001480-C-T		not specified	Uncertain significance (Nov 18, 2022)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Gene ontology

• Biological process: monocyte chemotaxis;inflammatory response;G protein-coupled receptor signaling pathway;regulation of signaling receptor activity;neutrophil chemotaxis;positive regulation of GTPase activity;eosinophil chemotaxis;lymphocyte chemotaxis;chemokine-mediated signaling pathway;positive regulation of ERK1 and ERK2 cascade;cellular response to interferon-gamma;cellular response to interleukin-1;cellular response to tumor necrosis factor
• Cellular component: extracellular space
• Molecular function: chemokine activity;CCR chemokine receptor binding