CORO6

protein-coding

coronin 6, the group of WD repeat domain containing|Coronins

Gene summary

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to be located in lamellipodium. Predicted to be active in actin filament and plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

MANE transcript

NM_032854.4

Inheritance

—

ClinVar variants

U:89B:2

Top phenotype

Breast ductal adenocarcinoma

gnomAD constraint

pLI —, LoF o/e 0.61

Max pathogenic AF

—

Genomic locus

chr17:29,614,756-29,622,912

External References & Databases

Ensembl (ENSG00000167549)

Transcript & Mutation Effects

hg38 • Region Span ~8.2 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to CORO6 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 82

Breast ductal adenocarcinomaTotal: 1

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_032854.4. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			1 clinvar			1
missense			84 clinvar	2 clinvar		86
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			4 clinvar			4
Total	0	0	89	2	0	91

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 147 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_032854.4	RefSeq	NP_116243.2	10	MANE Select
ENST00000388767.8	Ensembl	ENSP00000373419.3	10	MANE Select
NM_001351301.3	RefSeq	NP_001338230.1	6	Standard
NM_001351302.3	RefSeq	NP_001338231.1	6	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Molecular Function

protein binding

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000345068
Coding exons: 10
Length: 8152
Individuals with no LoFs: 125681
Homozygous LoFs: 1
Heterozygous LoFs: 66
Defined: 125748
p: 0.000266

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.449	273	295	0.926	0.0000168	3087
Missense (PolyPhen)		95	112.63	0.84344		1131
Synonymous	1.30	102	120	0.849	0.00000731	926
Loss of Function	1.67	13	21.3	0.610	0.00000104	227

Population LoF Frequency

Population	CAF	p-value	Status
African	0.00020	0.00018	rare
Latino/Admixed American	0.00026	0.00026	rare
Ashkenazi Jewish	0.0028	0.0027	notable
East Asian	0.00022	0.00022	rare
Finnish	0.000094	0.000092	rare
European (Non-Finnish)	0.00011	0.00011	rare
South Asian	0.00020	0.00020	rare
Other	0.00066	0.00065	rare

dbNSFP Gene Annotations

Source: dbNSFP

Intolerance Scores

LoFtool: 0.670
RVIS EVS: -0.25
RVIS percentile EVS: 35.75

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Indispensability pred.: N
Indispensability score: 0.192

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium