FAM66B

family with sequence similarity 66 member B, the group of Long non-coding RNAs with FAM root symbol

Basic information

Region (hg38): 8:7263163-7355364

Links

ENSG00000215374 ∙ NCBI:100128890 ∙ ∙ HGNC:28890 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the FAM66B gene.

• not provided (6 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the FAM66B gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding				6		6
Total	0	0	0	6	0

Variants in FAM66B

This is a list of pathogenic ClinVar variants found in the FAM66B region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
8-7296399-T-C			not provided (-)
8-7333183-C-T			Likely benign (Dec 01, 2022)
8-7333291-A-T			Likely benign (Nov 01, 2022)
8-7333568-C-T			Likely benign (Jan 01, 2023)
8-7333694-C-G			Likely benign (Dec 01, 2022)
8-7337236-C-A			Likely benign (Jan 01, 2023)
8-7338417-G-A			Likely benign (Feb 01, 2023)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Essentials

• gene_indispensability_pred: N
• gene_indispensability_score: 0.231