FAM66C

family with sequence similarity 66 member C, the group of Long non-coding RNAs with FAM root symbol

Basic information

Region (hg38): 12:8180204-8226278

Links

ENSG00000226711 ∙ NCBI:440078 ∙ ∙ HGNC:21644 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the FAM66C gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the FAM66C gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

Variants in FAM66C

This is a list of pathogenic ClinVar variants found in the FAM66C region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
12-8221826-T-C		not specified	Uncertain significance (Mar 06, 2025)
12-8221860-G-A		not specified	Likely benign (Mar 04, 2024)
12-8221910-C-G		not specified	Likely benign (Sep 01, 2021)
12-8221917-A-G		not specified	Uncertain significance (Sep 01, 2021)
12-8221952-G-A		not specified	Uncertain significance (Jul 06, 2021)
12-8221952-G-C		not specified	Uncertain significance (Jul 19, 2023)
12-8221958-G-A		not specified	Uncertain significance (Jul 06, 2021)
12-8221980-A-T		not specified	Uncertain significance (Feb 10, 2022)
12-8221993-C-G			Likely benign (Oct 01, 2022)
12-8222010-G-A		not specified	Uncertain significance (Jan 24, 2025)
12-8222013-C-T		not specified	Uncertain significance (Oct 29, 2024)
12-8222019-C-G		not specified	Uncertain significance (Sep 13, 2023)
12-8222050-G-A			Likely benign (Mar 01, 2023)
12-8222074-G-T		not specified	Uncertain significance (Feb 22, 2025)
12-8222085-T-C		not specified	Uncertain significance (Jun 17, 2024)
12-8222090-C-T		not specified	Uncertain significance (Jan 08, 2025)
12-8222093-G-A		not specified	Uncertain significance (Nov 20, 2024)
12-8222112-A-G		not specified	Uncertain significance (Jul 06, 2021)
12-8222114-G-C		not specified	Uncertain significance (Aug 02, 2021)
12-8222124-G-A		not specified	Uncertain significance (Nov 25, 2024)
12-8222142-C-T		not specified	Uncertain significance (Jan 23, 2024)
12-8222150-A-G		not specified	Uncertain significance (Apr 12, 2024)
12-8222185-C-CACG			Benign (Aug 09, 2017)
12-8222208-C-T		not specified	Uncertain significance (May 30, 2023)
12-8222237-G-A		not specified	Uncertain significance (Jan 25, 2025)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Essentials

• gene_indispensability_pred: N
• gene_indispensability_score: 0.231