FPR2

protein-coding

formyl peptide receptor 2, the group of Formyl peptide receptors|Leukotriene receptors

Gene summary

Enables amyloid-beta binding activity; scavenger receptor binding activity; and signaling receptor activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of ERK1 and ERK2 cascade; and regulation of defense response. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Previous symbols:

FPRL1

MANE transcript

NM_001005738.2

Inheritance

—

ClinVar variants

U:41B:4

Top phenotype

Lung adenocarcinoma

gnomAD constraint

pLI —, LoF o/e 0

Max pathogenic AF

—

Genomic locus

chr19:51,752,026-51,770,531

External References & Databases

Ensembl (ENSG00000171049)

Transcript & Mutation Effects

hg38 • Region Span ~18.5 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to FPR2 variants in ClinVar

3 Conditions Cataloged

not specifiedTotal: 43

not providedTotal: 2

Lung adenocarcinomaTotal: 1

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001005738.2. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				1 clinvar		1
missense			41 clinvar	3 clinvar		44
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	41	4	0	45

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 12 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001005738.2	RefSeq	NP_001005738.1	1	MANE Select
ENST00000340023.7	Ensembl	ENSP00000340191.4	1	MANE Select
NM_001462.3	RefSeq	NP_001453.1	1	Standard
ENST00000598776.1	Ensembl	ENSP00000468897.1	1	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Pathways ConsensusPathDB

Staphylococcus aureus infection - Homo sapiens (human)
Neuroactive ligand-receptor interaction - Homo sapiens (human)
Peptide GPCRs
GPCRs, Class A Rhodopsin-like
Signaling by GPCR

Biological Process

microglial cell activation
positive regulation of protein phosphorylation
complement receptor mediated signaling pathway
receptor-mediated endocytosis
chemotaxis

Molecular Function

amyloid-beta binding
G protein-coupled receptor activity
N-formyl peptide receptor activity
scavenger receptor binding
cargo receptor activity

Cellular Component

cytoplasm
plasma membrane
integral component of membrane
specific granule membrane
tertiary granule membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000598776
Coding exons: 1
Length: 18501
Individuals with no LoFs: 123252
Homozygous LoFs: 0
Heterozygous LoFs: 1
Defined: 123253
p: 0.00000406

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.608	168	192	0.877	0.0000109	2275
Missense (PolyPhen)		31	51.813	0.59831		722
Synonymous	-0.754	85	76.6	1.11	0.00000413	768
Loss of Function	0.959	0	1.07	0.00	4.46e-8	15

Population LoF Frequency

Population	CAF	p-value	Status
African	0	0.0	absent
Latino/Admixed American	0	0.0	absent
Ashkenazi Jewish	0	0.0	absent
East Asian	0	0.0	absent
Finnish	0	0.0	absent
European (Non-Finnish)	0	0.0	absent
South Asian	0.000033	0.000033	rare
Other	0	0.0	absent

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).;

Recessive Scores

pRec: 0.221

Intolerance Scores

LoFtool: 0.532
RVIS EVS: -0.31
RVIS percentile EVS: 31.93

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.129

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium