GGT3P
pseudogamma-glutamyltransferase 3 pseudogene, the group of Gamma-glutamyltransferases
Gene summary
Predicted to enable glutathione gamma-glutamate hydrolase. Predicted to be involved in several processes, including glutathione catabolic process; leukotriene D4 biosynthetic process; and peptide modification. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jun 2026]
- GGT3
MANE transcript
Inheritance
ClinVar variants
Top phenotype
Max pathogenic AF
Genomic locus
External References & Databases
GenCC Phenotypes & Disease Associations
Curated gene-disease validity assertions and inheritance patterns
No GenCC data available for this gene.
ClinVar Associated Diseases & Phenotypes
Reported disease conditions connected to GGT3P variants in ClinVar
No annotated ClinVar phenotypes.
ClinVar Variants & Pathogenicity by Type
Statistics based on transcript . Only rare variants are included.
We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.
Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.
| Effect | PathogenicP | Likely pathogenicLP | VUS | Likely benignLB | BenignB | Sum |
|---|---|---|---|---|---|---|
| synonymous | 0 | |||||
| missense | 0 | |||||
| nonsense | 0 | |||||
| start loss | 0 | |||||
| frameshift | 0 | |||||
| splice donor/acceptor (+/-2bp) | 0 | |||||
| Total | 0 | 0 | 0 | 0 | 0 | 0 |
Transcript Catalog
Annotated transcript isoforms across RefSeq and Ensembl databases
| Transcript ID | Source | Protein ID | Coding Exons | MANE Status |
|---|---|---|---|---|
| No transcripts match your selected source or search query. | ||||
Gene Ontology (GO) Annotations & Pathways
Biological processes, molecular functions, cellular components and pathways
Pathways ConsensusPathDB
- Glutathione conjugation
- Phase II - Conjugation of compounds
- Biological oxidations
- Metabolism
- Glutathione synthesis and recycling
Biological Process
- regulation of immune system process
- translation
- proteolysis
- cellular amino acid metabolic process
- glutamate metabolic process
Molecular Function
- peptidyltransferase activity
- molecular_function
- glutathione hydrolase activity
- hypoglycin A gamma-glutamyl transpeptidase activity
- leukotriene C4 gamma-glutamyl transferase activity
Cellular Component
- integral component of membrane
- extracellular exosome
dbNSFP Gene Annotations
Source:
- Function
- FUNCTION: Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. {ECO:0000250}.;
Recessive Scores
- pRec
- 0.0998