GHRLOS

ghrelin opposite strand/antisense RNA, the group of Long non-coding RNAs with non-systematic symbols

Basic information

Region (hg38): 3:10285754-10294903

Links

ENSG00000240288 ∙ NCBI:100126793 ∙ OMIM:618445 ∙ HGNC:33885 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the GHRLOS gene.

• not provided (8 variants)
• Inborn genetic diseases (7 variants)
• Obesity (4 variants)
• Metabolic syndrome, susceptibility to (2 variants)
• Obesity, age at onset of (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the GHRLOS gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			9	1	5	15
Total	0	0	9	1	5

Variants in GHRLOS

This is a list of pathogenic ClinVar variants found in the GHRLOS region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
3-10286566-A-C			Benign (Nov 12, 2018)
3-10286724-A-T		not specified	Uncertain significance (Oct 25, 2022)
3-10286758-G-C		not specified	Uncertain significance (May 28, 2024)
3-10286769-T-A		Obesity	Benign (Jun 09, 2021)
3-10286773-C-T		not specified	Uncertain significance (Jan 31, 2022)
3-10286782-GC-G		Obesity	Uncertain significance (Aug 12, 2021)
3-10286799-A-G		not specified	Uncertain significance (Feb 14, 2024)
3-10287098-G-A			Benign (Nov 12, 2018)
3-10287125-T-C			Benign (Nov 12, 2018)
3-10289760-A-C			Uncertain significance (Jul 01, 2022)
3-10289764-G-A		not specified	Uncertain significance (Jul 26, 2024)
3-10289773-G-T		Metabolic syndrome, susceptibility to • Obesity, age at onset of • Inherited obesity • Obesity	Conflicting classifications of pathogenicity (Dec 19, 2024)
3-10289785-C-A		not specified	Uncertain significance (Dec 26, 2023)
3-10289811-G-A		not specified	Uncertain significance (Aug 17, 2022)
3-10289814-C-T		not specified	Likely benign (Jan 18, 2023)
3-10289820-C-A		not specified	Uncertain significance (Dec 22, 2023)
3-10289835-C-T		Metabolic syndrome, susceptibility to • Obesity	risk factor (Dec 01, 2005)
3-10289914-C-T			Benign (Jun 20, 2021)
3-10290074-T-C		not specified	Uncertain significance (Apr 12, 2023)
3-10290080-C-G		not specified	Uncertain significance (Oct 17, 2023)
3-10290098-A-G		not specified	Uncertain significance (Jun 21, 2023)
3-10292847-C-T		not specified	Uncertain significance (Feb 13, 2023)
3-10292863-G-A			Likely benign (Jul 01, 2024)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP