GPR137

G protein-coupled receptor 137, the group of 7TM uncharacterized proteins

Basic information

Region (hg38): 11:64270061-64289500

Links

ENSG00000173264 ∙ NCBI:56834 ∙ ∙ HGNC:24300 ∙ Uniprot:Q96N19 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the GPR137 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the GPR137 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous			1			1
missense			11			11
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			13	2		15
Total	0	0	25	2	0

Variants in GPR137

This is a list of pathogenic ClinVar variants found in the GPR137 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
11-64270237-C-A		not specified	Uncertain significance (Apr 05, 2023)
11-64270238-C-G		not specified	Uncertain significance (Apr 01, 2024)
11-64270261-T-C		not specified	Uncertain significance (Oct 22, 2021)
11-64270285-C-T		not specified	Uncertain significance (Nov 10, 2022)
11-64270328-G-A		not specified	Uncertain significance (May 10, 2024)
11-64271745-G-C		not specified	Likely benign (Feb 16, 2023)
11-64271747-C-T		not specified	Uncertain significance (Mar 21, 2022)
11-64271755-C-A		not specified	Uncertain significance (Feb 07, 2023)
11-64271798-C-T		not specified	Uncertain significance (Mar 01, 2023)
11-64284223-C-T		not specified	Uncertain significance (Dec 23, 2022)
11-64284272-C-T		not specified	Uncertain significance (Dec 19, 2022)
11-64284275-A-C		not specified	Uncertain significance (Feb 12, 2024)
11-64284391-T-C		not specified	Uncertain significance (Aug 16, 2021)
11-64286781-G-C		not specified	Uncertain significance (Jan 03, 2024)
11-64286993-G-A		not specified	Uncertain significance (Sep 14, 2022)
11-64287004-A-G		not specified	Uncertain significance (Aug 11, 2022)
11-64287776-G-A		not specified	Uncertain significance (Dec 03, 2021)
11-64287798-A-C		not specified	Uncertain significance (Feb 28, 2023)
11-64288084-C-T		not specified	Uncertain significance (Sep 20, 2023)
11-64288155-T-A		not specified	Uncertain significance (Oct 22, 2021)
11-64288171-G-A		not specified	Uncertain significance (Mar 07, 2023)
11-64288609-A-G		not specified	Uncertain significance (Jun 10, 2022)
11-64288660-C-T		not specified	Uncertain significance (Jul 29, 2023)
11-64289192-C-T		not specified	Uncertain significance (Mar 01, 2023)
11-64289193-G-A		not specified	Uncertain significance (Jun 09, 2022)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
GPR137	protein_coding	protein_coding	ENST00000411458	9	19439

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.668	0.332	125734	0	12	125746	0.0000477

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	1.04	244	294	0.829	0.0000187	2982
Missense in Polyphen		62	96.855	0.64013		1084
Synonymous	0.413	125	131	0.954	0.00000819	1079
Loss of Function	3.44	4	21.1	0.190	0.00000116	205

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.0000544	0.0000544
Finnish	0.00	0.00
European (Non-Finnish)	0.0000887	0.0000879
Middle Eastern	0.0000544	0.0000544
South Asian	0.00	0.00
Other	0.000165	0.000163

dbNSFP

Source: dbNSFP

Recessive Scores

• pRec: 0.103

Intolerance Scores

• loftool: 0.601
• rvis_EVS: -0.42
• rvis_percentile_EVS: 25.56

Haploinsufficiency Scores

• pHI: 0.220
• hipred: N
• hipred_score: 0.407
• ghis: 0.552

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: S
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.143

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Gpr137

Gene ontology

• Cellular component: integral component of membrane