GPR150

G protein-coupled receptor 150, the group of G protein-coupled receptors, Class A orphans

Basic information

Region (hg38): 5:95620087-95622142

Links

ENSG00000178015 ∙ NCBI:285601 ∙ ∙ HGNC:23628 ∙ Uniprot:Q8NGU9 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the GPR150 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the GPR150 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			41	3		44
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	41	3	0

Variants in GPR150

This is a list of pathogenic ClinVar variants found in the GPR150 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
5-95620280-A-G		not specified	Uncertain significance (Feb 13, 2025)
5-95620284-T-G		not specified	Uncertain significance (Aug 30, 2022)
5-95620316-C-T		not specified	Uncertain significance (Mar 11, 2024)
5-95620321-A-G		not specified	Uncertain significance (Jan 23, 2024)
5-95620373-G-A		not specified	Uncertain significance (Jul 12, 2022)
5-95620418-T-A		not specified	Uncertain significance (Dec 30, 2024)
5-95620426-G-A		not specified	Uncertain significance (Mar 01, 2024)
5-95620426-G-C		not specified	Uncertain significance (Apr 09, 2024)
5-95620445-T-C		not specified	Uncertain significance (Jan 19, 2025)
5-95620486-G-A		not specified	Uncertain significance (Feb 18, 2025)
5-95620511-G-C		not specified	Uncertain significance (Dec 02, 2024)
5-95620513-C-T		not specified	Uncertain significance (Oct 26, 2024)
5-95620606-G-C		not specified	Uncertain significance (Mar 01, 2025)
5-95620637-C-A		not specified	Uncertain significance (Aug 28, 2024)
5-95620639-T-G		not specified	Uncertain significance (Jan 26, 2025)
5-95620649-T-G		not specified	Uncertain significance (Oct 02, 2023)
5-95620658-T-C		not specified	Uncertain significance (Jul 19, 2022)
5-95620717-C-T		not specified	Uncertain significance (Jul 14, 2021)
5-95620753-C-T		not specified	Uncertain significance (Apr 07, 2022)
5-95620760-G-A		not specified	Uncertain significance (Nov 27, 2024)
5-95620763-C-A		not specified	Uncertain significance (Sep 28, 2022)
5-95620766-T-G		not specified	Uncertain significance (Apr 26, 2024)
5-95620778-G-A		not specified	Uncertain significance (Mar 06, 2023)
5-95620801-G-A		not specified	Uncertain significance (Oct 16, 2023)
5-95620859-C-T		not specified	Uncertain significance (Jan 07, 2025)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
GPR150	protein_coding	protein_coding	ENST00000380007	1	2065

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.0000139	0.413	0	0	0	0	0.00

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	0.606	162	185	0.875	0.00000856	2575
Missense in Polyphen		51	61.722	0.82629		868
Synonymous	1.08	76	89.0	0.854	0.00000426	1038
Loss of Function	0.390	8	9.28	0.862	4.06e-7	95

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.00	0.00
Middle Eastern	0.00	0.00
South Asian	0.00	0.00
Other	0.00	0.00

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Orphan receptor.
• Pathway: Olfactory receptor activity;Signaling by GPCR;Signal Transduction;G alpha (s) signalling events;GPCR downstream signalling (Consensus)

Recessive Scores

• pRec: 0.102

Haploinsufficiency Scores

• pHI: 0.272
• hipred: N
• hipred_score: 0.285
• ghis: 0.420

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.00206

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Gpr150

Gene ontology

• Biological process: G protein-coupled receptor signaling pathway;cellular response to hormone stimulus
• Cellular component: plasma membrane;integral component of plasma membrane
• Molecular function: G protein-coupled receptor activity