GPR155

G protein-coupled receptor 155

Basic information

Region (hg38): 2:174431571-174487094

Links

ENSG00000163328 ∙ NCBI:151556 ∙ ∙ HGNC:22951 ∙ Uniprot:Q7Z3F1 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the GPR155 gene.

• not_specified (96 variants)
• not_provided (7 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the GPR155 gene is commonly pathogenic or not. These statistics are base on transcript: NM_000152529.7. Only rare variants are included in the table.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Effect	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous				2	4	6
missense			94	3		97
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	94	5	4

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
GPR155	protein_coding	protein_coding	ENST00000392552	15	54857

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
6.04e-16	0.540	125650	0	98	125748	0.000390

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	1.61	360	457	0.788	0.0000221	5713
Missense in Polyphen		112	160.16	0.69931		2005
Synonymous	0.699	153	164	0.931	0.00000824	1694
Loss of Function	1.69	30	41.8	0.718	0.00000216	497

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.000689	0.000685
Ashkenazi Jewish	0.0000992	0.0000992
East Asian	0.000109	0.000109
Finnish	0.000185	0.000185
European (Non-Finnish)	0.000425	0.000422
Middle Eastern	0.000109	0.000109
South Asian	0.000720	0.000719
Other	0.000491	0.000489

dbNSFP

Source: dbNSFP

Recessive Scores

• pRec: 0.0832

Intolerance Scores

• loftool: 0.946
• rvis_EVS: -1
• rvis_percentile_EVS: 8.47

Haploinsufficiency Scores

• pHI: 0.120
• hipred: N
• hipred_score: 0.216
• ghis: 0.530

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.0998

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Gpr155

Gene ontology

• Biological process: intracellular signal transduction;cognition;transmembrane transport
• Cellular component: integral component of membrane;extracellular exosome
• Molecular function: molecular_function