GPR155

protein-coding

G protein-coupled receptor 155

Gene summary

Enables cholesterol binding activity. Involved in several processes, including cellular response to amino acid starvation; cellular response to cholesterol; and positive regulation of TORC1 signaling. Located in extracellular exosome. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

MANE transcript

NM_152529.7

Inheritance

—

ClinVar variants

U:105B:9

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.72

Max pathogenic AF

—

Genomic locus

chr2:174,431,571-174,487,094

External References & Databases

Ensembl (ENSG00000163328)

Transcript & Mutation Effects

hg38 • Region Span ~55.5 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to GPR155 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 105

not providedTotal: 7

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_152529.7. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				2 clinvar	4 clinvar	6
missense			104 clinvar	3 clinvar		107
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			1 clinvar			1
Total	0	0	105	5	4	114

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 44 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_152529.7	RefSeq	NP_689742.4	15	MANE Select
ENST00000392552.7	Ensembl	ENSP00000376335.2	15	MANE Select
NM_001033045.4	RefSeq	NP_001028217.1	15	Standard
NM_001267050.2	RefSeq	NP_001253979.1	15	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

intracellular signal transduction
cognition
transmembrane transport

Molecular Function

molecular_function

Cellular Component

integral component of membrane
extracellular exosome

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000392552
Coding exons: 15
Length: 54857
Individuals with no LoFs: 125650
Homozygous LoFs: 0
Heterozygous LoFs: 98
Defined: 125748
p: 0.000390

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	1.61	360	457	0.788	0.0000221	5713
Missense (PolyPhen)		112	160.16	0.69931		2005
Synonymous	0.699	153	164	0.931	0.00000824	1694
Loss of Function	1.69	30	41.8	0.718	0.00000216	497

Population LoF Frequency

Population	CAF	p-value	Status
African	0.00031	0.00031	rare
Latino/Admixed American	0.00038	0.00038	rare
Ashkenazi Jewish	0.000099	0.000099	rare
East Asian	0.00011	0.00011	rare
Finnish	0.00019	0.00018	rare
European (Non-Finnish)	0.00042	0.00042	rare
South Asian	0.00072	0.00072	rare
Other	0.00049	0.00049	rare

dbNSFP Gene Annotations

Source: dbNSFP

Recessive Scores

pRec: 0.0832

Intolerance Scores

LoFtool: 0.946
RVIS EVS: -1
RVIS percentile EVS: 8.47

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.0998

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium