GPR160

protein-coding

G protein-coupled receptor 160, the group of G protein-coupled receptors, Class A orphans

Gene summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of signaling receptor complex. [provided by Alliance of Genome Resources, Jun 2026]

MANE transcript

NM_014373.3

Inheritance

—

ClinVar variants

U:35B:3

Top phenotype

GPR160-related disorder

gnomAD constraint

pLI —, LoF o/e 0.64

Max pathogenic AF

—

Genomic locus

chr3:170,037,995-170,085,392

External References & Databases

Ensembl (ENSG00000173890)

Transcript & Mutation Effects

hg38 • Region Span ~47.4 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to GPR160 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 37

GPR160-related disorderTotal: 1

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_014373.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous						0
missense			35 clinvar	2 clinvar	1 clinvar	38
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	35	2	1	38

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 103 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_014373.3	RefSeq	NP_055188.1	1	MANE Select
ENST00000355897.10	Ensembl	ENSP00000348161.5	1	MANE Select
ENST00000473675.1	Ensembl	ENSP00000420751.1	1	Standard
ENST00000482710.1	Ensembl	ENSP00000419400.1	1	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

G protein-coupled receptor signaling pathway

Molecular Function

G protein-coupled receptor activity

Cellular Component

plasma membrane
integral component of membrane
receptor complex

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000355897
Coding exons: 1
Length: 47475
Individuals with no LoFs: 125507
Homozygous LoFs: 0
Heterozygous LoFs: 164
Defined: 125671
p: 0.000653

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.211	154	162	0.953	0.00000721	2221
Missense (PolyPhen)		37	37.683	0.98187		579
Synonymous	0.634	51	57.1	0.893	0.00000252	631
Loss of Function	1.02	6	9.36	0.641	3.89e-7	142

Population LoF Frequency

Population	CAF	p-value	Status
African	0.00025	0.00025	rare
Latino/Admixed American	0.00062	0.00061	rare
Ashkenazi Jewish	0	0.0	absent
East Asian	0.00027	0.00027	rare
Finnish	0.000093	0.000092	rare
European (Non-Finnish)	0.00038	0.00038	rare
South Asian	0.0031	0.0028	notable
Other	0.00050	0.00049	rare

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Orphan receptor.;

Recessive Scores

pRec: 0.0827

Intolerance Scores

LoFtool: 0.574
RVIS EVS: 0.37
RVIS percentile EVS: 75.12

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.366

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium