GPR87

G protein-coupled receptor 87, the group of G protein-coupled receptors, Class A orphans

Basic information

Region (hg38): 3:151294086-151316820

Previous symbols: [ "GPR95" ]

Links

ENSG00000138271 ∙ NCBI:53836 ∙ OMIM:606379 ∙ HGNC:4538 ∙ Uniprot:Q9BY21 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the GPR87 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the GPR87 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			32	1		33
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	32	1	0

Variants in GPR87

This is a list of pathogenic ClinVar variants found in the GPR87 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
3-151294177-C-A		not specified	Uncertain significance (Oct 29, 2021)
3-151294179-G-A		not specified	Uncertain significance (Oct 29, 2021)
3-151294186-C-A		not specified	Uncertain significance (Oct 29, 2021)
3-151294206-G-C		not specified	Uncertain significance (Jan 19, 2024)
3-151294315-G-A		not specified	Uncertain significance (Jan 09, 2025)
3-151294375-T-C		not specified	Uncertain significance (Jan 03, 2024)
3-151294392-T-A		not specified	Uncertain significance (Nov 30, 2022)
3-151294396-A-C		not specified	Uncertain significance (Jun 23, 2021)
3-151294458-G-T		not specified	Uncertain significance (Jan 01, 2025)
3-151294474-C-T		not specified	Uncertain significance (Sep 16, 2021)
3-151294477-C-T		not specified	Uncertain significance (Aug 17, 2022)
3-151294517-C-G		not specified	Uncertain significance (Apr 20, 2024)
3-151294525-T-G		not specified	Uncertain significance (Oct 26, 2022)
3-151294566-A-G		not specified	Uncertain significance (Aug 13, 2021)
3-151294639-A-G		not specified	Uncertain significance (Sep 20, 2024)
3-151294647-C-T		not specified	Uncertain significance (Aug 20, 2024)
3-151294660-T-G		not specified	Uncertain significance (Oct 13, 2023)
3-151294689-T-G		not specified	Uncertain significance (Aug 06, 2021)
3-151294713-A-G		not specified	Uncertain significance (Jan 04, 2024)
3-151294713-A-T		not specified	Uncertain significance (Oct 29, 2021)
3-151294753-C-T			Likely benign (Dec 01, 2024)
3-151294790-C-T		not specified	Uncertain significance (Jul 25, 2023)
3-151294836-A-G		not specified	Uncertain significance (Apr 08, 2023)
3-151294894-A-C		not specified	Uncertain significance (Feb 09, 2025)
3-151294981-T-C		not specified	Uncertain significance (Sep 09, 2024)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
GPR87	protein_coding	protein_coding	ENST00000260843	2	22850

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.00000481	0.423	125701	1	41	125743	0.000167

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-0.264	207	197	1.05	0.0000104	2366
Missense in Polyphen		104	99.872	1.0413		1215
Synonymous	-0.522	82	76.2	1.08	0.00000447	688
Loss of Function	0.506	9	10.8	0.834	6.92e-7	136

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.000297	0.000297
Ashkenazi Jewish	0.00	0.00
East Asian	0.000435	0.000435
Finnish	0.000185	0.000185
European (Non-Finnish)	0.000141	0.000141
Middle Eastern	0.000435	0.000435
South Asian	0.000229	0.000229
Other	0.00	0.00

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. {ECO:0000269|PubMed:17905198, ECO:0000269|PubMed:19602589}.
• Pathway: GPCRs, Class A Rhodopsin-like (Consensus)

Recessive Scores

• pRec: 0.111

Intolerance Scores

• loftool: 0.553
• rvis_EVS: 0.35
• rvis_percentile_EVS: 74.37

Haploinsufficiency Scores

• pHI: 0.228
• hipred: N
• hipred_score: 0.444
• ghis: 0.536

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.136

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Gpr87
• Phenotype: skeleton phenotype; limbs/digits/tail phenotype

Gene ontology

• Biological process: G protein-coupled receptor signaling pathway;negative regulation of adenylate cyclase activity;biological_process;G protein-coupled purinergic nucleotide receptor signaling pathway
• Cellular component: plasma membrane;integral component of membrane
• Molecular function: G protein-coupled purinergic nucleotide receptor activity