GSTT4

glutathione S-transferase theta 4, the group of Soluble glutathione S-transferases

Basic information

Region (hg38): 22:23998401-24005453

Previous symbols: [ "GSTTP1" ]

Links

ENSG00000276950

∙ NCBI:25774 ∙ ∙ HGNC:26930 ∙ Uniprot:A0A1W2PR19 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the GSTT4 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the GSTT4 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous				1 clinvar		1
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	1	0

Variants in GSTT4

This is a list of pathogenic ClinVar variants found in the GSTT4 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
22-24001286-T-C			Likely benign (Mar 01, 2023)	2652979

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Function: FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000250|UniProtKB:P30711}.;

Recessive Scores

pRec: 0.105

Mouse Genome Informatics

Gene name: Gstt4
Phenotype

Gene ontology

Biological process
Cellular component: cytoplasm
Molecular function: glutathione transferase activity