HNF1A-AS1

ncRNA

HNF1A antisense RNA 1, the group of Antisense RNAs

Gene summary

Biomarker of colon cancer and stomach cancer. [provided by Alliance of Genome Resources, Jul 2025]

Previous symbols:

C12orf27
NCRNA00262

MANE transcript

N/A

Inheritance

—

ClinVar variants

—

Top phenotype

Monogenic diabetes

Max pathogenic AF

—

Genomic locus

chr12:120,941,723-120,980,968

External References & Databases

Ensembl (ENSG00000241388)

GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to HNF1A-AS1 variants in ClinVar

16 Conditions Cataloged

Monogenic diabetesTotal: 101

not providedTotal: 78

Maturity onset diabetes mellitus in youngTotal: 67

not specifiedTotal: 34

Maturity-onset diabetes of the young type 3Total: 30

6 conditionsTotal: 12

Nonpapillary renal cell carcinomaTotal: 8

Type II diabetes mellitusTotal: 3

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript . Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB
synonymous
missense
nonsense
start loss
frameshift
splice donor/acceptor (+/-2bp)
Total	0	0	0	0	0

Highest pathogenic variant AF is 0.00000733374

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 0 of 0 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
No transcripts match your selected source or search query.

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate (By similarity). {ECO:0000250}.;

Recessive Scores

pRec: 0.245