HOMEZ

protein-coding

homeobox and leucine zipper encoding, the group of ZF class homeoboxes and pseudogenes

Gene summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

KIAA1443

MANE transcript

NM_020834.3

Inheritance

—

ClinVar variants

U:87B:6

Top phenotype

—

Max pathogenic AF

—

Genomic locus

chr14:23,272,422-23,299,796

External References & Databases

Ensembl (ENSG00000290292)

Transcript & Mutation Effects

hg38 • Region Span ~27.4 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to HOMEZ variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 91

not providedTotal: 1

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_020834.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				1 clinvar		1
missense			87 clinvar	5 clinvar		92
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	87	6	0	93

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 8 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_020834.3	RefSeq	NP_065885.2	2	MANE Select
ENST00000357460.7	Ensembl	ENSP00000350049.4	2	MANE Select
ENST00000561013.3	Ensembl	ENSP00000453979.1	2	Standard
ENST00000606731.2	Ensembl	ENSP00000475307.3	2	Standard