HSP90B2P

heat shock protein 90 beta family member 2, pseudogene

Basic information

Region (hg38): 15:99257632-99260015

Previous symbols: [ "TRAP1", "TRA1P1", "HSPCP2" ]

Links

ENSG00000259706

∙ NCBI:7190 ∙ ∙ HGNC:12099 ∙ Uniprot:Q58FF3 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the HSP90B2P gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the HSP90B2P gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Function: FUNCTION: Putative molecular chaperone. {ECO:0000250}.;

Recessive Scores

pRec: 0.126

Intolerance Scores

loftool
rvis_EVS: -0.34
rvis_percentile_EVS: 30.08

Haploinsufficiency Scores

pHI: 0.230
hipred: N
hipred_score: 0.498
ghis

Mouse Genome Informatics

Gene name: Trap1
Phenotype: liver/biliary system phenotype; hematopoietic system phenotype; neoplasm; immune system phenotype; growth/size/body region phenotype; endocrine/exocrine gland phenotype; cellular phenotype; homeostasis/metabolism phenotype;

Gene ontology

Biological process: protein folding
Cellular component
Molecular function: ATP binding;unfolded protein binding