IFNG-AS1

IFNG antisense RNA 1, the group of Antisense RNAs

Basic information

Region (hg38): 12:67989446-68234686

Links

ENSG00000255733 ∙ NCBI:100885789 ∙ ∙ HGNC:43910 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the IFNG-AS1 gene.

• Aplastic anemia (19 variants)
• not provided (15 variants)
• Inborn genetic diseases (13 variants)
• Immunodeficiency 69 (2 variants)
• not specified (1 variants)
• Tsc2 angiomyolipomas, renal, modifier of (1 variants)
• Mycobacterium tuberculosis, protection against (1 variants)
• Acquired immunodeficiency syndrome, rapid progression to (1 variants)
• Hepatitis C virus infection, response to therapy of (1 variants)
• Aplastic anemia, susceptibility to (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the IFNG-AS1 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding	2		28	4	6	40
Total	2	0	28	4	6

Highest pathogenic variant AF is 0.00691

Variants in IFNG-AS1

This is a list of pathogenic ClinVar variants found in the IFNG-AS1 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
12-68154814-T-C		Aplastic anemia	Benign (Jan 13, 2018)
12-68154853-G-A		Aplastic anemia	Likely benign (Jan 13, 2018)
12-68154888-T-A		Aplastic anemia	Likely benign (Jan 13, 2018)
12-68155122-A-G		Aplastic anemia	Uncertain significance (Jan 12, 2018)
12-68155166-A-C		Aplastic anemia	Uncertain significance (Jan 13, 2018)
12-68155173-G-A		Aplastic anemia	Benign (Jan 13, 2018)
12-68155246-T-C		Aplastic anemia	Uncertain significance (Jan 13, 2018)
12-68155252-TTTGA-T		Aplastic anemia	Uncertain significance (Jun 14, 2016)
12-68155331-A-T		Aplastic anemia	Uncertain significance (Jan 12, 2018)
12-68155344-G-A		Aplastic anemia	Uncertain significance (Jan 12, 2018)
12-68155423-G-A		Aplastic anemia	Uncertain significance (Jan 12, 2018)
12-68155423-G-T		Aplastic anemia	Uncertain significance (Apr 28, 2017)
12-68155427-G-T		not specified	Uncertain significance (Apr 01, 2024)
12-68155445-T-C			Uncertain significance (Nov 30, 2021)
12-68155466-G-A		not specified	Uncertain significance (Sep 28, 2022)
12-68155714-C-G			not provided (-)
12-68155769-A-T			not provided (-)
12-68155906-A-G			not provided (-)
12-68157553-C-G			not provided (-)
12-68157563-T-A			not provided (-)
12-68157629-C-T			Benign (Nov 12, 2018)
12-68157774-A-G			not provided (-)
12-68157921-TAGTC-T		Immunodeficiency 69	Pathogenic (Mar 23, 2022)
12-68157954-T-C		not specified	Uncertain significance (May 31, 2023)
12-68157994-G-A		Aplastic anemia	Uncertain significance (Jan 12, 2018)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Mouse Genome Informatics

• Gene name: Ifngas1