LENG9

leukocyte receptor cluster member 9

Basic information

Region (hg38): 19:54461732-54463778

Links

ENSG00000275183 ∙ NCBI:94059 ∙ ∙ HGNC:16306 ∙ Uniprot:Q96B70 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the LENG9 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the LENG9 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous				2		2
missense			54	6		60
nonsense						0
start loss			1			1
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			4			4
Total	0	0	59	8	0

Variants in LENG9

This is a list of pathogenic ClinVar variants found in the LENG9 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
19-54462124-G-C		not specified	Uncertain significance (Jun 07, 2024)
19-54462140-C-G		not specified	Uncertain significance (Aug 12, 2024)
19-54462142-A-G		not specified	Likely benign (Oct 26, 2021)
19-54462146-G-A		not specified	Uncertain significance (Mar 07, 2025)
19-54462152-G-T		not specified	Uncertain significance (Feb 06, 2025)
19-54462179-C-A		not specified	Uncertain significance (Sep 23, 2023)
19-54462205-A-C		not specified	Uncertain significance (Jul 13, 2021)
19-54462249-G-A			Likely benign (Mar 01, 2023)
19-54462255-G-T		not specified	Uncertain significance (Sep 10, 2024)
19-54462259-G-A		not specified	Uncertain significance (Jan 26, 2025)
19-54462272-C-T		not specified	Uncertain significance (Nov 08, 2024)
19-54462302-C-T		not specified	Uncertain significance (Oct 18, 2021)
19-54462303-T-G		not specified	Uncertain significance (Sep 14, 2022)
19-54462310-C-T		not specified	Uncertain significance (Jul 10, 2024)
19-54462316-C-G		not specified	Uncertain significance (Sep 03, 2024)
19-54462340-A-G		not specified	Uncertain significance (Nov 09, 2024)
19-54462359-C-G		not specified	Uncertain significance (Mar 01, 2023)
19-54462373-G-A		not specified	Uncertain significance (May 30, 2024)
19-54462374-G-A		not specified	Uncertain significance (Mar 03, 2025)
19-54462400-C-T		not specified	Uncertain significance (Jul 26, 2024)
19-54462409-G-C		not specified	Uncertain significance (Jan 02, 2025)
19-54462413-G-T		not specified	Uncertain significance (Apr 23, 2024)
19-54462424-C-T		not specified	Uncertain significance (Jul 11, 2023)
19-54462469-T-G		not specified	Likely benign (Feb 15, 2023)
19-54462479-C-T		not specified	Likely benign (Aug 02, 2021)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Haploinsufficiency Scores

• pHI: 0.650
• hipred: N
• hipred_score: 0.153

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: E
• gene_indispensability_pred: N
• gene_indispensability_score: 0.165

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	High	Medium	High
Primary Immunodeficiency	High	High	High
Cancer	High	High	High

Mouse Genome Informatics

• Gene name: Leng9

Gene ontology

• Molecular function: metal ion binding