LIM2-AS1

LIM2 and SIGLEC10 antisense RNA 1, the group of Antisense RNAs

Basic information

Region (hg38): 19:51387085-51412636

Links

ENSG00000268889 ∙ NCBI:105372446 ∙ ∙ HGNC:56004 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the LIM2-AS1 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the LIM2-AS1 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

Variants in LIM2-AS1

This is a list of pathogenic ClinVar variants found in the LIM2-AS1 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
19-51387156-C-G		Cataract 19 multiple types	Uncertain significance (Jan 12, 2018)
19-51387161-C-T		Inborn genetic diseases	Uncertain significance (Nov 09, 2021)
19-51387182-T-C		Cataract 19 multiple types	Uncertain significance (Jul 21, 2020)
19-51387186-T-C		Cataract 19 multiple types • LIM2-related disorder	Likely benign (Jun 14, 2023)
19-51387192-A-G		Cataract 19 multiple types	Uncertain significance (Apr 27, 2017)
19-51387213-G-A		Cataract 19 multiple types	Uncertain significance (Jan 13, 2018)
19-51387219-C-T		Cataract 19 multiple types	Conflicting classifications of pathogenicity (Sep 26, 2023)
19-51387223-C-T		Cataract 19 multiple types	Uncertain significance (Oct 13, 2023)
19-51387238-G-A			Uncertain significance (Mar 06, 2024)
19-51387239-C-T		Cataract 19 multiple types	Uncertain significance (Jan 13, 2018)
19-51387240-G-A		LIM2-related disorder	Likely benign (Mar 19, 2021)
19-51387241-C-T		Cataract 19 multiple types • Inborn genetic diseases	Uncertain significance (Jul 20, 2021)
19-51387258-G-A		Cataract 19 multiple types	Benign/Likely benign (Jul 23, 2023)
19-51387262-G-A		Inborn genetic diseases	Uncertain significance (Oct 29, 2021)
19-51387270-G-A		Cataract 19 multiple types	Uncertain significance (Jan 13, 2018)
19-51387286-A-G		LIM2-related disorder	Uncertain significance (Feb 09, 2023)
19-51387300-G-A		Cataract 19 multiple types	Likely benign (Oct 06, 2023)
19-51387303-C-G		Cataract 19 multiple types	Uncertain significance (Jan 13, 2018)
19-51387313-C-T		Cataract 19 multiple types • Inborn genetic diseases	Uncertain significance (Apr 11, 2023)
19-51387314-G-A		Inborn genetic diseases	Uncertain significance (Mar 13, 2023)
19-51387336-G-A		Cataract 19 multiple types	Uncertain significance (Jan 12, 2018)
19-51387344-A-T		Cataract 19 multiple types	Uncertain significance (Apr 27, 2017)
19-51387350-G-A		Inborn genetic diseases	Uncertain significance (Apr 05, 2023)
19-51387366-G-A			Likely benign (Nov 01, 2024)
19-51387387-C-T		Cataract 19 multiple types • LIM2-related disorder • Inborn genetic diseases	Conflicting classifications of pathogenicity (Dec 27, 2023)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP