MAP10

protein-coding

microtubule associated protein 10

Gene summary

Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Located in microtubule cytoskeleton and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Previous symbols:

KIAA1383

MANE transcript

NM_019090.3

Inheritance

—

ClinVar variants

U:127B:18

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.99

Max pathogenic AF

—

Genomic locus

chr1:232,805,416-232,809,929

External References & Databases

Ensembl (ENSG00000212916)

Transcript & Mutation Effects

hg38 • Region Span ~4.5 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to MAP10 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 143

not providedTotal: 2

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_019090.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				1 clinvar		1
missense			127 clinvar	15 clinvar	2 clinvar	144
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	127	16	2	145

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 2 of 2 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_019090.3	RefSeq	NP_061963.3	1	MANE Select
ENST00000418460.4	Ensembl	ENSP00000403208.2	1	MANE Select

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

cytoplasmic microtubule organization
positive regulation of cytokinesis
regulation of microtubule-based process
mitotic spindle midzone assembly
cell division

Molecular Function

microtubule binding

Cellular Component

centrosome
cytoplasmic microtubule
midbody
mitotic spindle pole
mitotic spindle midzone

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000418460
Coding exons: 1
Length: 5450
Individuals with no LoFs: 0
Homozygous LoFs: 0
Heterozygous LoFs: 0
Defined: 0
p: 0.00

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-1.32	632	545	1.16	0.0000256	6780
Missense (PolyPhen)		149	130.49	1.1419		1773
Synonymous	-3.12	281	222	1.27	0.0000107	2095
Loss of Function	0.0442	31	31.3	0.991	0.00000140	433

Population LoF Frequency

Population	CAF	p-value	Status
African	0	0.0	absent
Latino/Admixed American	0	0.0	absent
Ashkenazi Jewish	0	0.0	absent
East Asian	0	0.0	absent
Finnish	0	0.0	absent
European (Non-Finnish)	0	0.0	absent
South Asian	0	0.0	absent
Other	0	0.0	absent

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis. {ECO:0000269|PubMed:23264731}.;

Intolerance Scores

RVIS EVS: 0.74
RVIS percentile EVS: 86.35

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium