GeneBe

MEG3

maternally expressed 3, the group of MicroRNA non-coding host genes|Long non-coding RNAs with non-systematic symbols

Basic information

Region (hg38): 14:100779206-100861031

Links

ENSG00000214548 ∙ NCBI:55384 ∙ OMIM:605636 ∙ HGNC:14575 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MEG3 gene.

  • not provided (10 variants)
  • MEG3-related condition (1 variants)
  • Paternal uniparental disomy of chromosome 14 (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MEG3 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type Pathogenic Likely pathogenic VUS Likely benign Benign Sum
synonymous
0
missense
0
nonsense
0
start loss
0
frameshift
0
inframe indel
0
splice donor/acceptor (+/-2bp)
1
clinvar
 1
splice region
0
non coding
1
clinvar
1
clinvar
5
clinvar
4
clinvar
 11
Total 1 0 2 5 4

Variants in MEG3

This is a list of pathogenic ClinVar variants found in the MEG3 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position Type Phenotype Significance ClinVar
14-100779738-G-A Benign (Mar 01, 2024)3067539
14-100804356-TGAGGCCCAGCTCAGCCCTGCGCTCTGCAGGTCTCCCTGGTAAACGGCTTCCTGGTCCTCATCGGAAGGCAGGGGCCGCCCGGCGCTCCCCTGGACCTGACGGGGAGGCTGTCTTGCTCGTGTCCGTGGACCATCCACCCACAGTGGAGCCCTAGGGATGAGGAGGGACATGAAGTTGAGTGGTGAAGGGGAGACCCCATGGGAGGTGAGAAGCCAGCCCAGGGAGGAGGGTGAACAAAGTCTCCTTTTTTTTTCCAGACCTCTTCCAGCCCATGCTACATGACCCATGAGAAAGAGCAGAGCTGGGACGCAGGTCCCCGGGACTGGCATCTTCACGCTGTATCACACAGCGGCCTTTCATCGCCTCCTCTGTTCAAGGGAAACCAGCAAACCTGCTCCCTGGACTTTGTGGGACTGAGGCTGCCGCTCTGGGGAAACATTCCATCCAGTTCTGGACCCAGGAGGGCTCATCAAGTATTCATCTCACCCCTTTGCATTTCAAAAGGGAAGGTTTTCAGGCAAGGTGAGCTTGCATTCAAAGGAAAATGCATCTCTCAAAGTCAGCAAAGGCCCCCAGTCCTTTTTGGGGTTCAGCTTTTACCCCATGCTGCATGTAATCTACCTGGTCAGAGAGAGATGGCTTCACAAGACACAAAGGTGAATCTGCCCGCATCCTCCCTGGTCCTCCCCTGAGGCCACAAGGACACCCCTGGGCCTGTTAGAGCTAGGGGCACCTTAAAACTGAGCATGTCTCCCGACCCTCCAGGGGTGACACTGAGCTCTGTGGAGAAGCCCTTTCCTCCAGGACTGTCTTCTGAAATGCCAGGAACCCAACTGTGTGTGACAGGGCTCCCCCAGGGAAGCAGAATGGGGAGGGAGTTTAGAAAAGGGCTAAGAAACCACACTCTGCACAGCCACAGACCATTGCATTCTTCGGTTTTTGTTTTGTGTTTTCTCTTTTCTTCTTCTTCTCTCTCTCTTTTTTTTAAACAAGAAACAAGAATTATTCCTGTAATTGTCTTAAAGGTTAAAATATTATGACGGTTCCCTGATCGGGCTGTTGGGAGAATTAAATGCGATGAGGCTCCAGGGAACGTCAGTGTGGCTTTGGGGACTGCTGCGGCTGTGTACGAAAAAGGATGGCACTTCTGCCACCAGGATCCTTTCCCTCAGTCGTCCATGGGGAGCTGTTTGGGCCCCTCAGTTAGTCACTCATCAAATCCTGGCTCCTGGCATCTTCCACGTGTCAGAATCCTTTACCAGTCCTCCAGGGAGACCCTGCCTGCATCCTAATGGCACACTCAAGTCTTTGAGAGGAATTTTCAGTCATCAGGAACTTTCGGGGCCAAATTCTTACTAGAATATTTAAGCGCTCTGGATCTGCCAAGCCCCTGCCCCCAAACTCCTTTCTCCAGCAAGGGCTTGTGGCACCTGAGCCCCCAACCTCCATGTCAAATGTTGAGAAGCTCCTCATGGCTGCCCTCCCCAGCCCTGTCTCCATGGTTCTGTGATGGGGGATTTTGCACCCCGAAAGTTGCCTTTTCAGCAGCACACAGAGGCCTGGGACTGTTACAGGACTGGGATCTAACCTTAGCGCTGCCAGTGGAAAAAGTCAAGTGACTTCACTTTTCTTTTCTTTTCTTTTTTGAGACTGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCCGTTGACTGCAATCTTCGCCTCGCAGGTTCAAGTGATTCTCCTGCTTCAGCCTCTGGAGTAGCTGGGATTATAGGCATGTGCCACCACACGCCTATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGTCTGGTCTCAAACTCCTGACCTCGGGTGATCCTCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCGGCCGCTTTTCTAGTTAGGCACCTATAATATTGGAGAATAACAAAAATACACCTCCAGGGATTCATGTGAGGATGCGGCGAAATAAATGTCAGGTCAAGGTCAATCGCCTCTGAGATCTCAGCGAATTAAAGAGTTGGCAGCGATCTGGCAGCCTGGGGGTCCCTGAAGAGCCCTCCTCACAGTGGAGTTGGGTGGAGGTCTCCCCAGCCCCCAGGAGACAGTGATGAGCTGGCCCAGCTCCCAGCCTGAGCTATCCAATCCTCTGAGCTCCTCTCCCCGCCTGGGGCAGGGGTGGTGCTGGCTCAGCAGGAAGCGAATGGAAGCAAACTGCCCTGGGGGTGGTGGTGTTTGGTCTGAGGAGCGGCTCCTGGCTGTTGCTTTAAGGAGAGAAGCACTGGCCGGGAGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGTAGATCACCTGGAGGTCAAGAGTTCAAGACCAGCTTGGCCAATATGGCGGAACCCCGTTTCTGCAAAAATACAAAAATTAGTCTGGGCGCGGTGGCTCACGCCTGTGATCCCAGCACTTCAGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAAATGGTGAAACCCCATCTCTACCAAAAAATACAAAAACTGGCTGGACATGGTGGTGGGCACTTGTAATCCCAGCTACTTGGGAGGTGAGGCAAAAGAATCTCTCGAACCTGGGAGGAGGAGGCCGCAGTGAGCTGAGATGGCGCCACTGCACTCCAGCCTGAGTGACAGAGCGAGACTCTGTCTCAAAAATAAAAAAAATAATAATAAAAGAAGAGAAGATCGGCTGTGGTGGCTCATGCTTGTAATCCCAGCACTTTGGGAAGCCCAGGGGGGCAGATCACCTGAGGTTGGGCGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCTGGGCGTGGTGGTGCACGCCTATAATCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCACGCTATTGCACTTTAGCCTGTGCAACAAGAGCAAAACTCCGTCTCAGGAAAAAAAAAAAAAAAAGACGAAGAGAAACAAAGCAGAATTCATTTTCCACCACTCTAACCTGGTCATGCTAGCTTGAAAATGTCCAAAGGTGGTGGGGTTGAGAAGGTAGGTGATCACGACGGGAGGCCTGCCCAGCCCCAACCCCTTCTTAAGTGCAACCCTGGGGACTTTGGAGTCAGGCTTTAGGGTCACCCTAAGGCTGCTGAGATGGAGAGCAGGGACCCAACCAGCGGTGTTGCGGTTTGCCCTGCATCATGCCGCTGAGTGCCAGGCTCGCTCGGCCCACCGGTCACTGGCACGCTTGCTTCCCACCACTATTAACGGTGTTGTGGTCTCCTGGTTCCCATGCCTGGAGGGGCTTTGGTACCCCGTGACCTCAAGTTGCCATATGCCTTGACTCTCTGCATCAGCTCACTGCAGGAGGGTCCCCGTGCCCCTTACAGTGCTGGCGCCAATATCGTAGAAGCTACATTGTGTTTCATTCATTTGCTTACTGGCTGGGGATGGGGTTTGGGATTGCTGGAAGACTTTGCCCATGCTTAGGGAAATGTTCCTCCACGACCCCAAAGAGCTTTGCCCTTCAGGCCCCGGGCGAGAACGAGATAAATATGCTTAGTACTTGCTCTCACTTTGAACTTGGTAAATTTCAATCCCAAACCACCCCTGAGAGCCTGTCTGGAGACACTTGGCTCCTTTAAGAAGAGAGGCCCCACAGGGTTGGAGAAGATCAACAGCCCAAGGAATTACCTTCTGCTCTCCTGCTGTCTCACAAATAGCTCTGTCAGCTGGGGGCCTGAGCACTGGAACTGGCAAAGCACCCCTGTGGAATGAGAATGGACTCCTTCCTTGGGGAAGAGTACACTCCTCTTTTGTTTTTTTGGCCCTAGGGACTATAGAATCGAGTTCCGCATTTTTGATGTAATTTGACATTTGCAGGGTTCTCAAGACCTCCAACAGCGCTGAGCCCAGGAGTTGGATTGGGCTACTGGCTACTAGGTGATTAGGAAGTGAGGATTTCATGCCCCAGATCCTAAATAGGGGATCACAAACTTTGCAGGTCTGTGAGAGGCTATTTTCCTCTTGCCACGATTCGCCAGTGGCGCGTGGTTCGCCAGTGGTGCGTGGTTCGCCAGTGGTGCATGGTTCGCCAGTGGCCCGCAGTCTGGAACACCATAACTGGTGGGTACAATGACATTCCCTGGGTTCTTCTTTCTCCCTGCTCCACTGCTGCCAGATTGTGTTTTGCTGCTGCTTTTTTTTTTCCCCCAAGACGGGGTCTTGTACTGTTGCTCAGGCTGGCCTTGAACTCCTGACCTCAATGGATCCTTCTGTGTCAGCCTTTTGAGTAGCTAGGATCACAGGCGTGAGCCAGCACATCTGGCTCAGGCTGTGGTTTGTGCCCTCAGTTTACCATGAATTGCCAGGCATTCATTCATCTCTGATCCTTGGAGTGGTGTGTGGCTGTTCCCTGATCTAGGGGACTGGTGTCACCAGAACGGCTTTCCTCACCCACACCAAACTGTCCAGGGTTCGCTCTGTGCTTCTCCTACCTGGGATGAGAGAACTAGAACAGCAACAACCACCCTTCCCTGGGATGACTTTGGTAAATTTCACCCTTTGAGCAGCTCTGTAAAGCCTGCTGGGGATGTTCCTTTAAGAAGAGGAATACTAAAAAGCCCACCGAATTTCAGATGAGGCTTCCCACTCCTCTTACTGTTTTGCAAATGTCTTTCTCTGCCTGAAGCCTCCGCTTTGGGGCTAGCAAAGCGCCCTCCTGGCCCCCTCCGCCCTGAGGGAGACTTGCTGTCCTCTCTTCTTTTCATCTCTGGGGGCCAAGGAATTGAATTTTGGGGTATTTGAGGAGATTTGGCATCTGCAGCTTCATGCCAAGATGCTAACTACTCCTTGGACAAGAGAGCACATAGTCCTACCACTGAACTGGGTTTGCCAGTAGCCCGCGGTTCGCCATTTGCCCGCGGTTCTCTGATACACTTTAATTTGCTACAAAGGATCTGAGCTGCCCTGACCTGCTAGGCTTCCTGGCCCTTCCCTGCACCATCATTCCCTGTGATTCACCACACTTCACCCTGGTTTGCAACTTAATGCGTCTCTGAGATTCTCAGATCCGCAGGTTATCATTGCGGGGTATCTGTGTGAAATAATGCCAACCACTAATCCCAGGTAACTTTTTGCACCCTTTCGAGTATTTGCTGAAATTCTGCAGTAGGAATTGCCCCAGACCTTCATCCTGGCTTAGGGAAACCGTTCTGAGGGTCCCAAAGACCCAGTTCTCCCGTCGAAAACCCACCTGTGACCCCAGTTCTTTTCCTTGATGGTTTTTGCAACCCTGACCTGCTCAGTGAGTGAGAGGTGCCAGCCAGTCTGGTGTTCTGTAAAACTGGAGAACGGAAGACCCATTTCCTAGCATTGTTGTACTGAATAAATGGAATGAATTTCATGGTATAGTTACTGAAAACACTACGAATTGTATAAGCATTTTGGTACCCATTCCCCTTCAGAACCACAAAATCCCTGATCTGCAGCTGGGGCTTGGGCGACCACACTACACTAGCTTTTCTTCATGTGTGGGGTGGACAGGTGAACCAGGTGAACTCTGCTCGGGTAGCTCCTTAATGTCTTGTGTCCACTCTGAGGTCATCCCATGTGGGATAAGGCAGGATAAGAAAAGCAACAACCATCCTCCCTGCCACCCCAAGATGAACTCTGTAAATTCTGTTCCTTACAGCCTGCCTAGGGACACCCTGTTTTTTTTTTTTTTAATGGAGTCTCACTCTGTTGCCCAGGCTGCAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCACCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCATGCCTGGATAATTTTTTGTATTTTTAGTAGGGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCACCTTGGCCTGAACACCCTGTTTTTTAAGAAGAGTAAGATAGGGTAGAGTTTAAAAGACTAAATAAAGAAAAAAAAAGAAAAGAAAGAAGGAAAAAACCAACTTGAACACTCTTGAACATCAGGGATGGGGCTACCCCCACCTGGCGCTGCTTGTTATGTAAATGACTCTCACCCGAGGAGGCCGGCAGATGCACCTGGCAGCTGGCTTGATCTTCCCTGAGAATGAAACCTGCTTTAGGTCTGAGTCTGAGTTATTGAATTTTGGGGTCTCTGAGGAGATTGACACCTTTAGCTTCACCCCAAGACTGCTAGCTCCTCCGCGTCCCCAAGTAGAGGGTGGGCAGCTGGGCATCTTGGGAACTGGGGCATTGTTTACACCCCAGGCTGGAATTGCTAAGAGTTTGTGGATCTGTGAGAAATGACTTCGCTCACTGGGCTGGGCCTTGCCAGTTGCCTGTGGTTCACCAGTTGCCCGCGGCTCACCAGTTGCCCGCGACTCACCAGGTGCCTGCGGCTCACCAGTTGCCTGTGGCTCACCAGCTGCCCGTGGCTCACCAGCTGCCCGTGGCTTACAGTTGCCCGAGGCTCACAGTTGCCCATGGCTTGCTAATTGCCAGCGATTTGCCAATTGCGAGTGGTTCGCCAGTTGCCCGCGGTCCGCTAAACCCGTAATCCTGTGGTACTGTAACTGGCCACAATGGACTCGCCCTTTAGGCTTCCCGGCCCTCTTTTGCCCAAATGCAGTTCTCAGCAGTGCAGTTCACTGTGATTCACCACAATTCGCCATGGTTTGTGATTTCATGGGTCTTGGTGATTCTCAGACCACAGGTTATCTACGGTCCTCAGGCAACTTCCTGCTTGCCCATTTGGAGGAAAGCTGCTGCCAAATTGCTCCAGGCTTGTGTCCTGCACCTCCCCCATCCGAAACTCTACATTTCAAGAGAAATGGAATCTTGATGCTTAGGCAACCCTCCCCCAATGCTCTTGGTTACAATGAATTAGCCAGAACTCAGCCCAAGGAATCCCTGCTGGAGGCCAATGGTGGGGGATGGTGGAGACAGAAGTGGGAAGGGCGGCACCTCCCATGCCCAGGTCCGCTTCTGCGCTCTCTGAGCTGTTTGAGCAGAGGTGGTGGAGACTGGGGGTCCTATCATTGAGGACTAGGTGGGTGTGGTACTTCTGCAGGCGCAACCCTGAGCTATCATAAACTGCAGCCCCAGCCTCATTCTCATTCCAACACACAAGAGCGCGCCATGGCCACACGCACACTCACACGTATAACGCACATGCACACTTTTGTCTGGAGCAGCTCCATCGCCATGAGATACATATTGATTGTTTCCTGGATCAAAAGGTGCAGGGGCTCAAGCTGTGTGTTGTCTGAGGAGGAGAATGAGTTATTCCTGTTCCCCGCCACTGGACAGAACTGTGGATCTTGCTTTTCCAAAGGGGAGAGCAGCAAGGCTGTCAGGAGACAGAAGAGGCTGGGAAGACCCGAGCTCACTGGGCAGAGGACCCCTTGGTTCTGTGGCCCCTGAAGCAACTGTCTCAGTGGGATGAGGTTTTTGGGACAGTGGTGTCTCTCTCGGGGAGAAGTCATAGCTTGAAGAATTCTCCTCCGCCCTTGACTTGCCCTACCTTCCCTGAGCTCTTTGTCATCTTGTTTGTGTCAAAAAGGGTGGATCTTGTCCTCTGTTTGAAGCAAGAAAAGGAAGTATCTGAGTGGTTAGCCCTGAGGGAGCCTTTTCCTTTTGACCTTTGACATTTGATCTGTTGCCAGTGATGGCAGGAGAGAGATGACGCTACAGGACCCGGCATGGCAGGGCCCCGGTGCTGGGCCTACTTGTCCTCTTAATGTCTCCTTCTCAAGCTGGTCACTTCCCTTGGGGCAGTGGAAGGAGGAGAATGACCTGGATGGCCAGATTGGCACTATCTCAGTGCTCCCATACAGAGCTGGGGCAAGTCTCTGGGCCTCTGTAAACCTCTCTTGAGGCATCTGTAAAAGTGGAGGATGGAAGCTCTGTTGGGGAGGATTTGGTAGTAAAAATAAATTTTAAGAGGAGTCCCGAACTAGTAGCACAGGGAACCCTAAAGAGCCCTGCTCTCCACTGGATGGAGAGCTGGCTCTTCCCAGGTCCCAGGAGGCAACACCGACTTTGCTGAGTCCCAAGCCTATCATGGGCTTTCCCACCCAGCCTGGGGCAAGGAGTGGAATACGCTTAGCCCAGGCAATGGATGGAAGCAAACTCCCCCAAGGAAGGTGGTATTAGTCTCCCTGGCCATTCCCAGTTGGAGTTGATTTGTTCCTTTAAGAAGGGGAAGGATTCTCGAGCACTGGAGTTTTCAGGTCCCCTCCCAGTCTTGAAAGTTTGCAAATGACTCTGTTTTGCGGGAGGGCTGAGGCTGAAGTCCTGTCCATCTCTATCCTCTGACTCTGAGGACTGAAGACTGGGCTTTAG-T Paternal uniparental disomy of chromosome 14 Pathogenic (Jun 01, 2010)162012
14-100829392-G-A MEG3-related disorder Likely benign (Jan 31, 2023)3040216
14-100829493-G-C MEG3-related disorder Benign (Aug 12, 2019)3059566
14-100831030-G-T MEG3-related disorder Benign/Likely benign (Oct 01, 2023)2644539
14-100831055-G-A MEG3-related disorder Likely benign (Mar 16, 2022)3054634
14-100831954-T-G Benign (Mar 01, 2024)2644540
14-100834631-G-T MEG3-related disorder Uncertain significance (May 11, 2023)2636776
14-100835004-G-A Benign (Jul 01, 2024)3239017
14-100835270-GC-G Likely benign (Jan 01, 2024)2644541
14-100835512-T-C Uncertain significance (Dec 01, 2022)2644542
14-100835704-G-A Likely benign (Aug 01, 2023)2644543
14-100836035-C-A MEG3-related disorder Likely benign (Feb 28, 2022)3043544
14-100836270-G-A MEG3-related disorder Likely benign (Apr 05, 2022)3034727
14-100836282-G-A MEG3-related disorder Likely benign (Jul 28, 2023)3042001
14-100845451-G-C MEG3-related disorder Benign (Sep 06, 2019)3056262
14-100845906-T-TG MEG3-related disorder Benign (Jan 08, 2020)3044287
14-100846076-G-A MEG3-related disorder Likely benign (Jul 28, 2022)3046639
14-100846316-C-T MEG3-related disorder Likely benign (Nov 11, 2022)3055213
14-100846864-AAG-A MEG3-related disorder Likely benign (Jun 27, 2022)3053082
14-100847719-TC-T MEG3-related disorder Likely benign (Jul 14, 2022)3035435
14-100848245-G-A MEG3-related disorder Likely benign (Jun 27, 2022)3053362
14-100848820-C-T MEG3-related disorder Likely benign (Jun 27, 2022)3052746
14-100848826-A-G MEG3-related disorder Benign (Sep 19, 2019)3056329
14-100849144-A-C MEG3-related disorder Benign (Nov 01, 2019)3056978

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Pathway
LncRNA-mediated mechanisms of therapeutic resistance (Consensus)

Haploinsufficiency Scores

pHI
0.453
hipred
hipred_score
ghis

Essentials

essential_gene_CRISPR
essential_gene_CRISPR2
essential_gene_gene_trap
gene_indispensability_pred
N
gene_indispensability_score
0.151

Mouse Genome Informatics

Gene name
Meg3
Phenotype
respiratory system phenotype; liver/biliary system phenotype; embryo phenotype; growth/size/body region phenotype; mortality/aging (the observable characteristics related to the ability of a mammalian organism to live and age that are manifested throughout development and life span); muscle phenotype; cellular phenotype;