MEG8

maternally expressed 8, small nucleolar RNA host gene, the group of Small nucleolar RNA non-coding host genes|MicroRNA non-coding host genes

Basic information

Region (hg38): 14:100883057-101038859

Previous symbols: [ "SNHG23", "SNHG24" ]

Links

ENSG00000225746 ∙ NCBI:79104 ∙ OMIM:613648 ∙ HGNC:14574 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MEG8 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MEG8 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

Variants in MEG8

This is a list of pathogenic ClinVar variants found in the MEG8 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
14-100883070-A-C		not specified	Likely benign (Apr 07, 2023)
14-100883086-G-C		not specified	Uncertain significance (Oct 10, 2023)
14-100883099-C-T		not specified	Uncertain significance (Dec 07, 2021)
14-100883117-G-T			Likely benign (-)
14-100883178-C-T			Likely benign (Sep 07, 2018)
14-100883218-G-A		not specified	Uncertain significance (Dec 19, 2022)
14-100883246-C-T		not specified	Uncertain significance (Dec 17, 2023)
14-100883261-G-C		not specified	Uncertain significance (Dec 21, 2023)
14-100883269-C-T		not specified	Uncertain significance (Sep 15, 2021)
14-100883270-G-A		not specified	Uncertain significance (Aug 02, 2023)
14-100883342-G-A		not specified	Uncertain significance (Jun 11, 2021)
14-100883344-A-G		not specified	Uncertain significance (Aug 12, 2021)
14-100883371-C-G		not specified	Uncertain significance (Aug 14, 2023)
14-100883394-C-T			Likely benign (Jan 08, 2018)
14-100883405-C-T		not specified	Uncertain significance (May 23, 2024)
14-100883519-C-T		not specified	Uncertain significance (Jul 25, 2023)
14-100883529-G-A			Likely benign (Sep 01, 2023)
14-100883572-C-T		not specified	Uncertain significance (Mar 21, 2024)
14-100883587-T-C		not specified	Conflicting classifications of pathogenicity (Sep 12, 2023)
14-100883594-C-T			Likely benign (Oct 01, 2023)
14-100883650-G-A		not specified	Uncertain significance (Jun 03, 2022)
14-100883659-C-T		not specified	Uncertain significance (Aug 28, 2023)
14-100883670-C-G		not specified	Uncertain significance (May 31, 2022)
14-100883772-G-C		not specified	Uncertain significance (Mar 01, 2024)
14-100883785-C-T		not specified	Uncertain significance (Mar 19, 2024)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Pathway: Vitamin D Receptor Pathway (Consensus)

Mouse Genome Informatics

• Gene name: Rian