MIIP

migration and invasion inhibitory protein, the group of MicroRNA protein coding host genes

Basic information

Region (hg38): 1:12019466-12032045

Links

ENSG00000116691 ∙ NCBI:60672 ∙ OMIM:608772 ∙ HGNC:25715 ∙ Uniprot:Q5JXC2 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MIIP gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MIIP gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous					4	4
missense			29	7	5	41
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	29	7	9

Variants in MIIP

This is a list of pathogenic ClinVar variants found in the MIIP region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
1-12021752-A-G		not specified	Uncertain significance (Sep 17, 2021)
1-12021767-A-G		not specified	Uncertain significance (Dec 21, 2023)
1-12021815-G-A		not specified	Uncertain significance (Jan 04, 2024)
1-12021838-G-A			Benign (Aug 18, 2017)
1-12022099-G-A		not specified	Uncertain significance (Jun 16, 2024)
1-12022150-C-T		not specified	Uncertain significance (Feb 28, 2023)
1-12022174-C-T		not specified	Uncertain significance (Jun 03, 2024)
1-12022186-G-A		not specified	Uncertain significance (Feb 15, 2023)
1-12022188-C-T		not specified	Uncertain significance (Mar 19, 2024)
1-12022189-G-A		not specified	Uncertain significance (Oct 04, 2022)
1-12022209-C-T		not specified	Uncertain significance (Apr 28, 2022)
1-12022215-G-T		not specified	Uncertain significance (Jan 07, 2022)
1-12022248-T-G		not specified	Uncertain significance (Dec 13, 2023)
1-12022263-C-T		not specified	Uncertain significance (Aug 22, 2023)
1-12022289-G-T		not specified	Uncertain significance (Feb 12, 2024)
1-12022306-C-T		not specified	Likely benign (Mar 14, 2023)
1-12022327-C-T		not specified	Likely benign (Mar 05, 2024)
1-12022378-A-G		not specified	Uncertain significance (Jul 21, 2021)
1-12022861-C-T		not specified	Uncertain significance (May 04, 2022)
1-12022872-A-G		not specified	Uncertain significance (May 02, 2024)
1-12022882-G-A		not specified	Uncertain significance (Jul 06, 2021)
1-12029068-C-T		not specified	Uncertain significance (Mar 30, 2024)
1-12029085-C-G			Benign (May 08, 2018)
1-12029106-A-G			Benign (May 08, 2018)
1-12029779-C-T		not specified	Uncertain significance (Dec 03, 2021)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
MIIP	protein_coding	protein_coding	ENST00000235332	9	12580

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
1.31e-20	0.000185	125506	1	238	125745	0.000951

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-0.224	257	247	1.04	0.0000162	2433
Missense in Polyphen		73	71.224	1.0249		786
Synonymous	0.750	95	105	0.907	0.00000645	842
Loss of Function	-1.17	27	21.2	1.27	0.00000122	208

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00257	0.00254
Ashkenazi Jewish	0.00	0.00
East Asian	0.00555	0.00556
Finnish	0.0000940	0.0000924
European (Non-Finnish)	0.000577	0.000563
Middle Eastern	0.00555	0.00556
South Asian	0.000396	0.000392
Other	0.000496	0.000489

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}.

Intolerance Scores

• loftool: 0.953
• rvis_EVS: 0.69
• rvis_percentile_EVS: 85.24

Haploinsufficiency Scores

• hipred: N
• hipred_score: 0.146
• ghis: 0.497

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: E
• gene_indispensability_score: 0.707

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Miip

Gene ontology

• Biological process: negative regulation of G2/M transition of mitotic cell cycle;negative regulation of cell migration
• Molecular function: protein binding