MIR17HG

miR-17-92a-1 cluster host gene, the group of MicroRNA non-coding host genes

Basic information

Previous symbols: [ "C13orf25", "MIRHG1" ]

Links

ENSG00000215417 ∙ NCBI:407975 ∙ OMIM:609415 ∙ HGNC:23564 ∙ Uniprot:Q75NE6 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

• Feingold syndrome type 2 (Strong), mode of inheritance: AD
• Feingold syndrome type 2 (Limited), mode of inheritance: AD
• Feingold syndrome type 2 (Limited), mode of inheritance: Unknown

Clinical Genomic Database

Source: CGD

Condition	Inheritance	Intervention Categories	Intervention/Rationale	Manifestation Categories	References
Feingold syndrome 2	AD	Cardiovascular	The condition can involve congenital cardiac anomalies, and awareness may allow early management	Cardiovascular; Endocrine; Musculoskeletal; Neurologic	21892160; 30672094

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MIR17HG gene.

• MIR17HG-related condition (5 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MIR17HG gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			5			5
Total	0	0	5	0	0

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

• Pathway: miRNA Regulation of DNA Damage Response (Consensus)

Haploinsufficiency Scores

• pHI: 0.165

Mouse Genome Informatics

• Gene name: Mir17hg

Gene ontology

• Cellular component: integral component of membrane