MIR1915HG

MIR1915 host gene, the group of MicroRNA non-coding host genes

Basic information

Region (hg38): 10:21487597-21497260

Previous symbols: [ "C10orf114", "CASC10" ]

Links

ENSG00000204682 ∙ NCBI:399726 ∙ ∙ HGNC:31448 ∙ Uniprot:Q5T4H9 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MIR1915HG gene.

• Inborn genetic diseases (7 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MIR1915HG gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			6	1		7
Total	0	0	6	1	0

Variants in MIR1915HG

This is a list of pathogenic ClinVar variants found in the MIR1915HG region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
10-21495614-C-G		not specified	Uncertain significance (Nov 19, 2024)
10-21495659-G-T		not specified	Uncertain significance (Apr 14, 2023)
10-21495687-G-C		not specified	Uncertain significance (May 23, 2023)
10-21495704-C-G		not specified	Uncertain significance (May 04, 2022)
10-21495706-G-C		not specified	Uncertain significance (Mar 19, 2024)
10-21495707-G-A		not specified	Likely benign (Jun 03, 2022)
10-21495715-G-A		not specified	Likely benign (Jan 30, 2024)
10-21495719-G-A		not specified	Uncertain significance (Jun 29, 2023)
10-21495719-G-C		not specified	Likely benign (Jul 27, 2024)
10-21495749-G-A		not specified	Likely benign (May 17, 2023)
10-21495754-A-C		not specified	Uncertain significance (Mar 28, 2022)
10-21495787-G-T		not specified	Uncertain significance (Jan 04, 2024)
10-21495791-C-T		not specified	Uncertain significance (Nov 15, 2024)
10-21495797-G-A		not specified	Uncertain significance (Jun 26, 2024)
10-21495815-G-C		not specified	Uncertain significance (Mar 02, 2023)
10-21495850-T-A		not specified	Uncertain significance (Oct 17, 2023)
10-21495890-C-T		not specified	Uncertain significance (Jul 20, 2021)
10-21495922-C-G		not specified	Uncertain significance (Feb 28, 2023)
10-21495922-C-T		not specified	Uncertain significance (Oct 02, 2023)
10-21495926-C-T		not specified	Uncertain significance (Oct 08, 2024)
10-21496771-C-T		not specified	Uncertain significance (Jul 19, 2023)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
MIR1915HG	protein_coding	protein_coding	ENST00000377113	2	4605

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.0848	0.572	116141	0	2	116143	0.00000861

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	-0.584	86	72.0	1.19	0.00000331	823
Missense in Polyphen		27	21.303	1.2675		248
Synonymous	-1.60	42	30.7	1.37	0.00000137	315
Loss of Function	-0.144	1	0.856	1.17	3.70e-8	13

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.0000597	0.0000597
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.00	0.00
Middle Eastern	0.00	0.00
South Asian	0.00	0.00
Other	0.00	0.00

dbNSFP

Source: dbNSFP

Haploinsufficiency Scores

• pHI: 0.0630
• hipred: N
• hipred_score: 0.204
• ghis: 0.537

Essentials

• essential_gene_CRISPR: N
• essential_gene_gene_trap: N

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium