MIR4435-2HG

MIR4435-2 host gene, the group of MicroRNA non-coding host genes

Basic information

Region (hg38): 2:111006015-111523376

Previous symbols: [ "MIR4435-1HG" ]

Links

ENSG00000172965 ∙ NCBI:541471 ∙ OMIM:617144 ∙ HGNC:35163 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MIR4435-2HG gene.

• Inborn genetic diseases (13 variants)
• not provided (2 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MIR4435-2HG gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			12	1	2	15
Total	0	0	12	1	2

Variants in MIR4435-2HG

This is a list of pathogenic ClinVar variants found in the MIR4435-2HG region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
2-111031628-T-C		not specified	Uncertain significance (Jul 29, 2023)
2-111031678-C-T		not specified	Uncertain significance (Jan 23, 2024)
2-111031693-T-G		not specified	Uncertain significance (Sep 21, 2023)
2-111092878-A-G		not specified	Uncertain significance (Aug 04, 2023)
2-111092905-G-A		not specified	Uncertain significance (Feb 28, 2024)
2-111092905-G-T		not specified	Uncertain significance (Jan 02, 2024)
2-111092911-G-T		not specified	Uncertain significance (Sep 07, 2022)
2-111092950-C-T		not specified	Likely benign (Oct 10, 2023)
2-111117769-C-T		not specified	Uncertain significance (Oct 12, 2021)
2-111123784-C-T			Benign (Dec 31, 2019)
2-111123785-C-G		not specified	Uncertain significance (Jun 07, 2024)
2-111123830-A-G		not specified	Uncertain significance (Aug 17, 2021)
2-111123848-T-C		not specified	Uncertain significance (Feb 27, 2024)
2-111123872-A-G		not specified	Uncertain significance (Dec 19, 2022)
2-111123885-A-G		not specified	Uncertain significance (Oct 06, 2022)
2-111123893-G-C		not specified	Uncertain significance (Jun 10, 2022)
2-111123954-C-G		not specified	Uncertain significance (Dec 01, 2022)
2-111124038-C-T		not specified	Uncertain significance (Feb 21, 2024)
2-111150070-G-A		not specified	Uncertain significance (Mar 23, 2023)
2-111150129-C-A		not specified	Uncertain significance (Mar 08, 2024)
2-111161417-A-G			Benign (Oct 28, 2020)
2-111164135-A-G		not specified	Likely benign (Jun 30, 2023)
2-111164196-C-T		not specified	Uncertain significance (May 10, 2024)
2-111164197-G-A		not specified	Uncertain significance (Dec 07, 2021)
2-111164202-A-G		not specified	Uncertain significance (Mar 25, 2024)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Haploinsufficiency Scores

• pHI: 0.0729

Mouse Genome Informatics

• Gene name: Gm14005