MIR4733HG

MIR4733 host gene, the group of MicroRNA non-coding host genes

Basic information

Links

ENSG00000264107 ∙ ∙ ∙ HGNC:55332 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MIR4733HG gene.

• Neurofibromatosis, type 1 (121 variants)
• Hereditary cancer-predisposing syndrome;Cardiovascular phenotype (33 variants)
• not provided (21 variants)
• Neurofibromatosis-Noonan syndrome (19 variants)
• Café-au-lait macules with pulmonary stenosis (19 variants)
• Neurofibromatosis, familial spinal (19 variants)
• Cardiovascular phenotype;Hereditary cancer-predisposing syndrome (17 variants)
• Hereditary cancer-predisposing syndrome (10 variants)
• not specified (2 variants)
• Abnormality of the skin (1 variants)
• Neurofibromatosis, type 1;Neurofibromatosis, familial spinal;Neurofibromatosis-Noonan syndrome;Café-au-lait macules with pulmonary stenosis;Juvenile myelomonocytic leukemia (1 variants)
• Juvenile myelomonocytic leukemia;Neurofibromatosis, familial spinal;Neurofibromatosis-Noonan syndrome;Café-au-lait macules with pulmonary stenosis;Neurofibromatosis, type 1 (1 variants)
• Neurofibromatosis, type 1;Neurofibromatosis-Noonan syndrome;Café-au-lait macules with pulmonary stenosis;Neurofibromatosis, familial spinal;Juvenile myelomonocytic leukemia (1 variants)
• NF1-related condition (1 variants)
• Juvenile myelomonocytic leukemia (1 variants)
• Juvenile myelomonocytic leukemia;Neurofibromatosis, type 1;Neurofibromatosis-Noonan syndrome;Café-au-lait macules with pulmonary stenosis;Neurofibromatosis, familial spinal (1 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MIR4733HG gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)			1			1
splice region						0
non coding	24	9	72	39	1	145
Total	24	9	73	39	1

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP