MIR6759

microRNA 6759, the group of MicroRNAs

Basic information

Region (hg38): 12:57748618-57748682

Links

ENSG00000283621 ∙ NCBI:102466729 ∙ ∙ HGNC:50063 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MIR6759 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MIR6759 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

Variants in MIR6759

This is a list of pathogenic ClinVar variants found in the MIR6759 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
12-57748620-G-A		Familial melanoma	Uncertain significance (Mar 26, 2021)
12-57748621-A-C		Hereditary cancer-predisposing syndrome • Familial melanoma	Conflicting classifications of pathogenicity (Nov 06, 2023)
12-57748621-A-G		Hereditary cancer-predisposing syndrome • Familial melanoma • Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 27, 2024)
12-57748621-AG-A		Familial melanoma	Uncertain significance (Nov 19, 2017)
12-57748622-G-A		Familial melanoma • Hereditary cancer-predisposing syndrome	Conflicting classifications of pathogenicity (Feb 07, 2024)
12-57748623-G-A		Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 27, 2024)
12-57748623-G-C		Familial melanoma	Likely benign (Jan 23, 2023)
12-57748623-G-GC		Familial melanoma • Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)
12-57748624-G-A		Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)
12-57748625-G-A		Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)
12-57748625-G-C		Familial melanoma	Likely benign (Apr 27, 2023)
12-57748625-G-T		Familial melanoma	Likely benign (Oct 20, 2023)
12-57748627-G-A		Familial melanoma	Likely benign (Nov 02, 2022)
12-57748629-G-A		Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)
12-57748630-G-A		Familial melanoma	Likely benign (May 19, 2023)
12-57748630-G-C		Familial melanoma	Likely benign (Apr 24, 2023)
12-57748631-C-T		Familial melanoma • Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)
12-57748631-CA-C		Familial melanoma	Likely benign (May 06, 2022)
12-57748632-A-C		Familial melanoma	Likely benign (Jan 29, 2024)
12-57748632-A-T		Familial melanoma	Likely benign (Dec 21, 2023)
12-57748634-A-G		Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)
12-57748636-G-A		Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)
12-57748637-T-A		Melanoma, cutaneous malignant, susceptibility to, 3	Likely benign (Sep 26, 2024)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP