MIR6774

microRNA 6774, the group of MicroRNAs

Basic information

Region (hg38): 16:85918347-85918416

Links

ENSG00000274134 ∙ NCBI:102466732 ∙ ∙ HGNC:50202 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MIR6774 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MIR6774 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

Variants in MIR6774

This is a list of pathogenic ClinVar variants found in the MIR6774 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
16-85918397-C-T		Immunodeficiency 32B;Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency	Likely benign (Dec 14, 2022)
16-85918398-G-A		Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency;Immunodeficiency 32B	Benign (Jan 01, 2024)
16-85918404-C-G		Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency;Immunodeficiency 32B	Uncertain significance (Oct 05, 2023)
16-85918406-C-T		Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency;Immunodeficiency 32B	Likely benign (Feb 14, 2023)
16-85918411-C-A		Immunodeficiency 32B;Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency	Likely benign (May 21, 2023)
16-85918417-C-T		Immunodeficiency 32B;Mendelian susceptibility to mycobacterial diseases due to partial IRF8 deficiency • Immunodeficiency 32B • not specified	Conflicting classifications of pathogenicity (Aug 01, 2024)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP