MORN4

MORN repeat containing 4

Basic information

Region (hg38): 10:97614553-97633500

Previous symbols: [ "C10orf83" ]

Links

ENSG00000171160 ∙ NCBI:118812 ∙ OMIM:617736 ∙ HGNC:24001 ∙ Uniprot:Q8NDC4 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MORN4 gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MORN4 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			8			8
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	8	0	0

Variants in MORN4

This is a list of pathogenic ClinVar variants found in the MORN4 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
10-97616296-G-C		not specified	Uncertain significance (Nov 09, 2021)
10-97616394-C-T		not specified	Uncertain significance (Apr 25, 2022)
10-97617244-T-C		not specified	Uncertain significance (Jun 16, 2023)
10-97617275-A-G		not specified	Uncertain significance (Dec 28, 2022)
10-97617277-G-A		not specified	Uncertain significance (May 23, 2024)
10-97617299-G-T		not specified	Uncertain significance (Nov 10, 2022)
10-97619596-A-G		not specified	Uncertain significance (Nov 30, 2022)
10-97619604-C-T		not specified	Uncertain significance (Jun 07, 2023)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
MORN4	protein_coding	protein_coding	ENST00000307450	4	19035

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p
0.550	0.438	125739	0	6	125745	0.0000239

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	0.342	76	84.9	0.895	0.00000495	952
Missense in Polyphen		15	18.232	0.82272		186
Synonymous	0.584	28	32.2	0.869	0.00000171	286
Loss of Function	2.01	1	6.57	0.152	3.44e-7	75

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.000118	0.000118
Ashkenazi Jewish	0.00	0.00
East Asian	0.00	0.00
Finnish	0.00	0.00
European (Non-Finnish)	0.0000182	0.0000176
Middle Eastern	0.00	0.00
South Asian	0.00	0.00
Other	0.00	0.00

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. {ECO:0000250|UniProtKB:Q6PGF2}.

Recessive Scores

• pRec: 0.0809

Intolerance Scores

• loftool: 0.431
• rvis_EVS: -0.1
• rvis_percentile_EVS: 46.2

Haploinsufficiency Scores

• pHI: 0.135
• hipred: N
• hipred_score: 0.478
• ghis: 0.585

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.440

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Morn4

Gene ontology

• Biological process: response to axon injury
• Cellular component: cytoplasm;stereocilium tip;filopodium tip
• Molecular function: protein binding