MRGPRG

MAS related GPR family member G, the group of G protein-coupled receptors, Class A orphans

Basic information

Region (hg38): 11:3217944-3218813

Previous symbols: [ "GPR169" ]

Links

ENSG00000182170 ∙ NCBI:386746 ∙ OMIM:607234 ∙ HGNC:24829 ∙ Uniprot:Q86SM5 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the MRGPRG gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the MRGPRG gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense			27	3		30
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	27	3	0

Variants in MRGPRG

This is a list of pathogenic ClinVar variants found in the MRGPRG region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
11-3217956-C-A		not specified	Uncertain significance (May 26, 2023)
11-3217997-C-T		not specified	Uncertain significance (Aug 17, 2021)
11-3218007-C-G		not specified	Uncertain significance (Jul 20, 2021)
11-3218029-G-A		not specified	Uncertain significance (Jul 20, 2021)
11-3218066-A-G		not specified	Uncertain significance (Aug 02, 2022)
11-3218128-G-T		not specified	Uncertain significance (Feb 21, 2024)
11-3218129-G-A		not specified	Uncertain significance (Feb 21, 2024)
11-3218168-A-T		not specified	Uncertain significance (Jul 20, 2021)
11-3218210-C-T		not specified	Uncertain significance (Jan 26, 2022)
11-3218216-C-A		not specified	Uncertain significance (Aug 08, 2023)
11-3218243-G-A		not specified	Uncertain significance (Oct 26, 2022)
11-3218305-A-T		not specified	Uncertain significance (Nov 07, 2022)
11-3218398-A-C		not specified	Uncertain significance (Aug 30, 2021)
11-3218440-A-G		not specified	Uncertain significance (Dec 03, 2021)
11-3218444-C-T		not specified	Likely benign (Feb 14, 2024)
11-3218464-C-T		not specified	Uncertain significance (Mar 15, 2023)
11-3218485-G-C		not specified	Uncertain significance (Nov 18, 2022)
11-3218563-A-G		not specified	Uncertain significance (Mar 29, 2024)
11-3218617-C-A		not specified	Uncertain significance (Jan 30, 2024)
11-3218618-C-A		not specified	Uncertain significance (Sep 13, 2022)
11-3218620-A-G		not specified	Uncertain significance (Dec 14, 2023)
11-3218621-C-T		not specified	Likely benign (Mar 13, 2023)
11-3218623-C-A		not specified	Uncertain significance (Oct 04, 2022)
11-3218645-C-A		not specified	Uncertain significance (Oct 28, 2023)
11-3218695-C-T		not specified	Likely benign (Apr 08, 2022)

GnomAD

Source: gnomAD

Gene	Type	Bio Type	Transcript	Coding Exons	Length
MRGPRG	protein_coding	protein_coding	ENST00000332314	1	870

pLI Probability LOF Intolerant	pRec Probability LOF Recessive	Individuals with no LOFs	Individuals with Homozygous LOFs	Individuals with Heterozygous LOFs	Defined	p

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible in Transcript
Missense	1.01	127	163	0.778	0.0000116	1773
Missense in Polyphen		28	40.837	0.68565		562
Synonymous	2.03	70	95.2	0.735	0.00000770	702
Loss of Function

LoF frequencies by population

Ethnicity	Sum of pLOFs	p
African & African-American	0.00	0.00
Ashkenazi Jewish
East Asian
Finnish
European (Non-Finnish)
Middle Eastern
South Asian
Other

dbNSFP

Source: dbNSFP

• Function: FUNCTION: Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). {ECO:0000250}.

Intolerance Scores

• rvis_EVS: 1.06
• rvis_percentile_EVS: 91.38

Haploinsufficiency Scores

• pHI: 0.0529

Essentials

• essential_gene_CRISPR: N
• essential_gene_CRISPR2: N
• essential_gene_gene_trap: N
• gene_indispensability_pred: N
• gene_indispensability_score: 0.152

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium

Mouse Genome Informatics

• Gene name: Mrgprg

Gene ontology

• Biological process: G protein-coupled receptor signaling pathway
• Cellular component: plasma membrane;integral component of membrane
• Molecular function: G protein-coupled receptor activity