MSLNL

pseudo

mesothelin like

Gene summary

Predicted to be involved in cell-matrix adhesion. Predicted to be located in membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Previous symbols:

C16orf37

MANE transcript

N/A

Inheritance

—

ClinVar variants

B:1

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 1.05

Max pathogenic AF

—

Genomic locus

chr16:769,428-782,054

External References & Databases

Ensembl (ENSG00000162006)

Transcript & Mutation Effects

hg38 • Region Span ~12.6 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to MSLNL variants in ClinVar

1 Conditions Cataloged

not providedTotal: 7

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript . Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				1 clinvar		1
missense						0
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	0	1	0	1

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Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 1 of 1 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
ENST00000543963.5	Ensembl	ENSP00000441381.1	15	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

cell-matrix adhesion

Cellular Component

cell surface
integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000293892
Coding exons: 16
Length: 13943
Individuals with no LoFs: 124376
Homozygous LoFs: 18
Heterozygous LoFs: 1084
Defined: 125478
p: 0.00440

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-1.36	725	629	1.15	0.0000422	6471
Missense (PolyPhen)		156	146.34	1.066		1765
Synonymous	-2.51	344	290	1.19	0.0000204	2344
Loss of Function	-0.285	38	36.1	1.05	0.00000173	401

Population LoF Frequency

Population	CAF	p-value	Status
African	0.050	0.041	notable
Latino/Admixed American	0.0042	0.0040	notable
Ashkenazi Jewish	0.00095	0.00090	rare
East Asian	0.00068	0.00065	rare
Finnish	0.00056	0.00051	rare
European (Non-Finnish)	0.0019	0.0017	notable
South Asian	0.0028	0.0026	notable
Other	0.0025	0.0023	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: May play a role in cellular adhesion. {ECO:0000250}.;

Recessive Scores

pRec: 0.0882

Essentials

Essential (CRISPR2): N
Indispensability pred.: N
Indispensability score: 0.123

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	High	High	High
Primary Immunodeficiency	High	High	High
Cancer	High	High	High