MYH7
myosin heavy chain 7, the group of MicroRNA protein coding host genes|Myosin heavy chains, class II
Basic information
Region (hg38): 14:23412739-23435660
Previous symbols: [ "CMH1", "MPD1" ]
Links
Phenotypes
GenCC
Source:
- hypertrophic cardiomyopathy 1 (Strong), mode of inheritance: AD
- myopathy, myosin storage, autosomal dominant (Moderate), mode of inheritance: AD
- dilated cardiomyopathy 1S (Strong), mode of inheritance: AD
- myopathy, myosin storage, autosomal recessive (Moderate), mode of inheritance: AR
- hypertrophic cardiomyopathy 1 (Definitive), mode of inheritance: AD
- MYH7-related skeletal myopathy (Strong), mode of inheritance: AD
- Ebstein anomaly (Supportive), mode of inheritance: AD
- familial isolated dilated cardiomyopathy (Supportive), mode of inheritance: AD
- hyaline body myopathy (Supportive), mode of inheritance: AD
- left ventricular noncompaction (Supportive), mode of inheritance: AD
- MYH7-related skeletal myopathy (Supportive), mode of inheritance: AD
- congenital myopathy 7A, myosin storage, autosomal dominant (Supportive), mode of inheritance: AD
- myopathy, myosin storage, autosomal recessive (Strong), mode of inheritance: AR
- dilated cardiomyopathy 1S (Definitive), mode of inheritance: AD
- hypertrophic cardiomyopathy 1 (Definitive), mode of inheritance: AD
- dilated cardiomyopathy 1S (Strong), mode of inheritance: AD
- MYH7-related skeletal myopathy (Strong), mode of inheritance: AD
- hypertrophic cardiomyopathy 1 (Strong), mode of inheritance: AD
- arrhythmogenic right ventricular cardiomyopathy (Limited), mode of inheritance: AD
- hypertrophic cardiomyopathy (Definitive), mode of inheritance: AD
- dilated cardiomyopathy (Definitive), mode of inheritance: AD
- MYH7-related skeletal myopathy (Definitive), mode of inheritance: AD
- congenital heart disease (Limited), mode of inheritance: AD
Clinical Genomic Database
Source:
| Condition | Inheritance | Intervention Categories | Intervention/Rationale | Manifestation Categories | References |
|---|---|---|---|---|---|
| Cardiomyopathy, dilated, 1S; Cardiomyopathy, familial hypertrophic 1; Myopathy, distal; Congenital myopathy 7B, myosin storage, autosomal recessive | AD/AR | Cardiovascular | Individuals can have cardiovascular anomalies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and arrhythmias, and surveillance and early treatment may be beneficial | Cardiovascular; Musculoskeletal | 13732753; 4104682; 1975517; 1361491; 1552912; 8254035; 8483915; 8343162; 8282798; 7909436; 8655135; 9544842; 10521296; 10424815; 11106718; 11102913; 11424919; 11733062; 11166161; 12379228; 14663035; 12975303; 12749056; 14520662; 14659406; 15136674; 15322983; 16267253; 15483641; 15699387; 16684601; 16650083; 17372140; 17548557; 17476457; 17336526; 18175163; 18506004; 19026577; 19138847; 19336582; 20503496; 20733148; 21395566; 21896538; 23117287; 23478172; 23956225; 25666907 |
| Compound heterozygosity and digenic inheritance (with MYLK2) has been described as an explanation for severe manifestations in some individuals |
ClinVar
This is a list of variants' phenotypes submitted to
- Hypertrophic cardiomyopathy (2951 variants)
- Cardiomyopathy (1381 variants)
- not provided (1282 variants)
- Cardiovascular phenotype (984 variants)
- not specified (712 variants)
- Hypertrophic cardiomyopathy 1 (295 variants)
- 6 conditions (205 variants)
- Myosin storage myopathy (177 variants)
- MYH7-related skeletal myopathy (176 variants)
- Dilated cardiomyopathy 1S (144 variants)
- Left ventricular noncompaction cardiomyopathy (89 variants)
- Primary familial hypertrophic cardiomyopathy (82 variants)
- Dilated Cardiomyopathy, Dominant (70 variants)
- Primary dilated cardiomyopathy (56 variants)
- Myopathy, myosin storage, autosomal recessive (25 variants)
- MYH7-related condition (20 variants)
- MYH7-Related Disorders (19 variants)
- Congenital myopathy with fiber type disproportion (16 variants)
- Scapuloperoneal myopathy (15 variants)
- See cases (13 variants)
- Familial cardiomyopathy (12 variants)
- Inborn genetic diseases (10 variants)
- Left ventricular noncompaction (7 variants)
- Primary familial dilated cardiomyopathy (7 variants)
- Hypertrophic cardiomyopathy 1;Dilated cardiomyopathy 1S (5 variants)
- Left ventricular noncompaction 5 (5 variants)
- Wolff-Parkinson-White pattern (4 variants)
- Long QT syndrome (3 variants)
- Restrictive cardiomyopathy (3 variants)
- Conduction disorder of the heart (3 variants)
- Arrhythmogenic right ventricular cardiomyopathy (2 variants)
- Ventricular fibrillation (2 variants)
- MYH7-related disease (2 variants)
- Dilated cardiomyopathy 1A (2 variants)
- Myopathy, myosin storage, autosomal recessive;Dilated cardiomyopathy 1S;Hypertrophic cardiomyopathy 1;Myosin storage myopathy;MYH7-related skeletal myopathy (2 variants)
- Myopathy (2 variants)
- Ebstein anomaly (1 variants)
- Sudden unexplained death;Hypertrophic cardiomyopathy (1 variants)
- 7 conditions (1 variants)
- Hyaline body myopathy (1 variants)
- Hypertrophic cardiomyopathy;Cardiac arrhythmia (1 variants)
- Primary dilated cardiomyopathy;Hypertrophic cardiomyopathy 1;Myosin storage myopathy;Left ventricular noncompaction (1 variants)
- Hypertrophic cardiomyopathy;Restrictive cardiomyopathy (1 variants)
- Hypertrophic cardiomyopathy 1;Myosin storage myopathy;Dilated cardiomyopathy 1S;MYH7-related skeletal myopathy (1 variants)
- Prolonged QT interval (1 variants)
- Congenital myopathy (1 variants)
- Atrial flutter;Tachycardia;Atrial fibrillation;Abnormal morphology of left ventricular trabeculae (1 variants)
- Hypertrophic cardiomyopathy 4 (1 variants)
- Cardiomyopathy, hypertrophic, midventricular, digenic (1 variants)
- Dyspnea;Hypertrophic cardiomyopathy (1 variants)
- Increased left ventricular wall thickness (1 variants)
- Arrhythmogenic cardiomyopathy (1 variants)
- Primary dilated cardiomyopathy;Left ventricular noncompaction cardiomyopathy (1 variants)
- First degree atrioventricular block (1 variants)
- Asymmetric septal hypertrophy (1 variants)
- Primary dilated cardiomyopathy;Congenital myopathy (1 variants)
- Ventricular fibrillation, paroxysmal familial, type 1 (1 variants)
- MYH7-related disorder (1 variants)
- Primary dilated cardiomyopathy;Hypotonia (1 variants)
- Idiopathic camptocormia (1 variants)
- Left ventricular noncompaction cardiomyopathy;Left ventricular hypertrophy (1 variants)
- 8 conditions (1 variants)
- Abnormality of the musculature (1 variants)
- Biventricular noncompaction cardiomyopathy;Hypertrophic cardiomyopathy (1 variants)
- Atrial septal defect (1 variants)
- Restrictive cardiomyopathy;Hypertrophic cardiomyopathy;Left ventricular noncompaction (1 variants)
- Dilated cardiomyopathy 1S;MYH7-related skeletal myopathy (1 variants)
- Dilated cardiomyopathy 1S;Hypertrophic cardiomyopathy 1 (1 variants)
- Ventricular tachycardia (1 variants)
- Sudden cardiac death (1 variants)
- Hypertrophic cardiomyopathy 1;Myopathy, myosin storage, autosomal recessive;Myosin storage myopathy;Dilated cardiomyopathy 1S;MYH7-related skeletal myopathy (1 variants)
- Sudden unexplained death (1 variants)
- Chest pain;Hypertrophic cardiomyopathy (1 variants)
- Familial isolated arrhythmogenic right ventricular dysplasia (1 variants)
- Primary dilated cardiomyopathy;Left ventricular noncompaction (1 variants)
- Myosin storage myopathy;Hypertrophic cardiomyopathy 1;Myopathy, myosin storage, autosomal recessive;Dilated cardiomyopathy 1S;MYH7-related skeletal myopathy (1 variants)
- Neuromuscular disease;Primary dilated cardiomyopathy (1 variants)
- Primary dilated cardiomyopathy;Hypertrophic cardiomyopathy (1 variants)
- Hypertrophic cardiomyopathy;Restrictive cardiomyopathy;Cardiomyopathy (1 variants)
- Primary dilated cardiomyopathy;Myocarditis (1 variants)
- Qualitative or quantitative defects of beta-myosin heavy chain (MYH7) (1 variants)
- Autosomal dominant MYH7-related disorder (1 variants)
Variants pathogenicity by type
Statistics on ClinVar variants can assist in determining whether a specific variant type in the MYH7 gene is commonly pathogenic or not.
In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.
Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.
| Variant type | Pathogenic | Likely pathogenic | VUS | Likely benign | Benign | Sum |
|---|---|---|---|---|---|---|
| synonymous | 10 | 744 | 44 | 798 | ||
| missense | 65 | 236 | 1727 | 10 | 2043 | |
| nonsense | 64 | 67 | ||||
| start loss | 2 | |||||
| frameshift | 77 | 80 | ||||
| inframe indel | 14 | 56 | 72 | |||
| splice donor/acceptor (+/-2bp) | 52 | 65 | ||||
| splice region ? | 1 | 101 | 111 | 8 | 221 | |
| non coding ? | 30 | 319 | 89 | 439 | ||
| Total | 72 | 263 | 2018 | 1073 | 140 |
Highest pathogenic variant AF is 0.0000853
Variants in MYH7
This is a list of pathogenic ClinVar variants found in the MYH7 region.
You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.
| Position | Type | Phenotype | Significance | ClinVar |
|---|---|---|---|---|
| 14-23412741-C-T | Hypertrophic cardiomyopathy • Dilated Cardiomyopathy, Dominant • Left ventricular noncompaction cardiomyopathy • Scapuloperoneal myopathy • Atrial septal defect • MYH7-related skeletal myopathy • Hypertrophic cardiomyopathy 1 • not specified • Myosin storage myopathy | Benign/Likely benign (Jan 13, 2018) | ||
| 14-23412749-A-G | Left ventricular noncompaction cardiomyopathy • Scapuloperoneal myopathy • MYH7-related skeletal myopathy • Dilated Cardiomyopathy, Dominant • Hypertrophic cardiomyopathy • Hypertrophic cardiomyopathy 1 • Myosin storage myopathy | Conflicting classifications of pathogenicity (Jan 13, 2018) | ||
| 14-23412773-C-T | Dilated cardiomyopathy 1S • MYH7-related skeletal myopathy • Hypertrophic cardiomyopathy 1 • Myosin storage myopathy | Uncertain significance (Jan 13, 2018) | ||
| 14-23412834-C-T | not specified • Dilated Cardiomyopathy, Dominant • Scapuloperoneal myopathy • Hypertrophic cardiomyopathy • Left ventricular noncompaction cardiomyopathy • MYH7-related skeletal myopathy • Hypertrophic cardiomyopathy 1 • Myosin storage myopathy | Benign/Likely benign (Jan 13, 2018) | ||
| 14-23412848-G-A | Cardiomyopathy | Uncertain significance (Jun 26, 2023) | ||
| 14-23412850-A-G | Likely benign (Nov 21, 2017) | |||
| 14-23412853-G-A | Likely benign (Jun 01, 2018) | |||
| 14-23412854-C-T | Hypertrophic cardiomyopathy • Cardiomyopathy • Cardiovascular phenotype | Conflicting classifications of pathogenicity (Dec 01, 2023) | ||
| 14-23412855-T-C | Congenital myopathy with fiber type disproportion • Hypertrophic cardiomyopathy • Myosin storage myopathy | Uncertain significance (Apr 29, 2018) | ||
| 14-23412860-C-T | Cardiomyopathy • Hypertrophic cardiomyopathy | Likely benign (Sep 05, 2023) | ||
| 14-23412862-C-T | Cardiomyopathy • Hypertrophic cardiomyopathy • Cardiovascular phenotype | Uncertain significance (Dec 05, 2023) | ||
| 14-23412864-T-A | Hypertrophic cardiomyopathy | Uncertain significance (Jul 13, 2021) | ||
| 14-23412864-T-C | Hypertrophic cardiomyopathy • Cardiomyopathy | Uncertain significance (May 16, 2022) | ||
| 14-23412865-T-G | Hypertrophic cardiomyopathy | Uncertain significance (Jul 03, 2023) | ||
| 14-23412869-G-A | MYH7-related skeletal myopathy • Dilated cardiomyopathy 1S • Hypertrophic cardiomyopathy 1 • Myosin storage myopathy • Hypertrophic cardiomyopathy | Conflicting classifications of pathogenicity (Aug 24, 2023) | ||
| 14-23412869-GC-G | Cardiovascular phenotype | Uncertain significance (May 24, 2019) | ||
| 14-23412872-CT-A | Hypertrophic cardiomyopathy | Uncertain significance (May 19, 2023) | ||
| 14-23412873-T-A | Cardiovascular phenotype | Uncertain significance (May 24, 2019) | ||
| 14-23412873-T-C | Hypertrophic cardiomyopathy | Uncertain significance (Jan 17, 2024) | ||
| 14-23412876-T-C | MYH7-related disorder | Likely benign (Dec 12, 2019) | ||
| 14-23412877-G-C | Hypertrophic cardiomyopathy | Uncertain significance (Sep 17, 2021) | ||
| 14-23412876-T-TGAAAG | Hypertrophic cardiomyopathy | Likely benign (Jul 03, 2023) | ||
| 14-23412890-G-A | Hypertrophic cardiomyopathy | Likely benign (Feb 22, 2023) | ||
| 14-23412935-T-C | Benign (Mar 03, 2015) | |||
| 14-23412977-T-G | Benign (Jun 14, 2018) |
GnomAD
Source:
| Gene | Type | Bio Type | Transcript | Coding Exons | Length |
|---|---|---|---|---|---|
| MYH7 | protein_coding | protein_coding | ENST00000355349 | 38 | 22981 |
| pLI Probability LOF Intolerant | pRec Probability LOF Recessive | Individuals with no LOFs | Individuals with Homozygous LOFs | Individuals with Heterozygous LOFs | Defined | p |
|---|---|---|---|---|---|---|
| 4.24e-16 | 1.00 | 125654 | 0 | 94 | 125748 | 0.000374 |
| Z-Score | Observed | Expected | Observed/Expected | Mutation Rate | Total Possible in Transcript | |
|---|---|---|---|---|---|---|
| Missense | 3.93 | 742 | 1.11e+3 | 0.668 | 0.0000785 | 12819 |
| Missense in Polyphen | 344 | 594.93 | 0.57822 | 7096 | ||
| Synonymous | -2.91 | 552 | 472 | 1.17 | 0.0000336 | 3631 |
| Loss of Function | 5.05 | 43 | 96.5 | 0.446 | 0.00000524 | 1183 |
LoF frequencies by population
| Ethnicity | Sum of pLOFs | p |
|---|---|---|
| African & African-American | 0.000600 | 0.000596 |
| Ashkenazi Jewish | 0.00 | 0.00 |
| East Asian | 0.000163 | 0.000163 |
| Finnish | 0.000324 | 0.000323 |
| European (Non-Finnish) | 0.000485 | 0.000475 |
| Middle Eastern | 0.000163 | 0.000163 |
| South Asian | 0.000392 | 0.000392 |
| Other | 0.000489 | 0.000489 |
dbNSFP
Source:
- Function
- FUNCTION: Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. {ECO:0000305|PubMed:26150528, ECO:0000305|PubMed:26246073}.;
- Disease
- DISEASE: Cardiomyopathy, familial hypertrophic 1 (CMH1) [MIM:192600]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269|PubMed:10065021, ECO:0000269|PubMed:10329202, ECO:0000269|PubMed:10521296, ECO:0000269|PubMed:10563488, ECO:0000269|PubMed:10679957, ECO:0000269|PubMed:10862102, ECO:0000269|PubMed:11113006, ECO:0000269|PubMed:11133230, ECO:0000269|PubMed:11214007, ECO:0000269|PubMed:11424919, ECO:0000269|PubMed:11733062, ECO:0000269|PubMed:11861413, ECO:0000269|PubMed:11968089, ECO:0000269|PubMed:12081993, ECO:0000269|PubMed:12566107, ECO:0000269|PubMed:12590187, ECO:0000269|PubMed:12707239, ECO:0000269|PubMed:12818575, ECO:0000269|PubMed:12820698, ECO:0000269|PubMed:12951062, ECO:0000269|PubMed:12974739, ECO:0000269|PubMed:12975413, ECO:0000269|PubMed:1417858, ECO:0000269|PubMed:15358028, ECO:0000269|PubMed:15483641, ECO:0000269|PubMed:1552912, ECO:0000269|PubMed:15563892, ECO:0000269|PubMed:15856146, ECO:0000269|PubMed:15858117, ECO:0000269|PubMed:16199542, ECO:0000269|PubMed:16267253, ECO:0000269|PubMed:1638703, ECO:0000269|PubMed:16650083, ECO:0000269|PubMed:16938236, ECO:0000269|PubMed:17095604, ECO:0000269|PubMed:17372140, ECO:0000269|PubMed:18175163, ECO:0000269|PubMed:18403758, ECO:0000269|PubMed:1975517, ECO:0000269|PubMed:25182012, ECO:0000269|PubMed:7581410, ECO:0000269|PubMed:7731997, ECO:0000269|PubMed:7848441, ECO:0000269|PubMed:7874131, ECO:0000269|PubMed:8250038, ECO:0000269|PubMed:8254035, ECO:0000269|PubMed:8268932, ECO:0000269|PubMed:8282798, ECO:0000269|PubMed:8343162, ECO:0000269|PubMed:8435239, ECO:0000269|PubMed:8483915, ECO:0000269|PubMed:8655135, ECO:0000269|PubMed:8899546, ECO:0000269|PubMed:9544842, ECO:0000269|PubMed:9822100, ECO:0000269|PubMed:9829907}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Myopathy, myosin storage, autosomal dominant (MSMA) [MIM:608358]: A rare congenital myopathy characterized by subsarcolemmal hyalinized bodies in type 1 muscle fibers. {ECO:0000269|PubMed:14520662, ECO:0000269|PubMed:15136674, ECO:0000269|PubMed:16684601, ECO:0000269|PubMed:17336526}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Scapuloperoneal myopathy MYH7-related (SPMM) [MIM:181430]: Progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm. {ECO:0000269|PubMed:17336526}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, dilated 1S (CMD1S) [MIM:613426]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269|PubMed:11106718, ECO:0000269|PubMed:12379228, ECO:0000269|PubMed:15769782, ECO:0000269|PubMed:18506004, ECO:0000269|PubMed:21127202, ECO:0000269|PubMed:21846512}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Myopathy, distal, 1 (MPD1) [MIM:160500]: A muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease. {ECO:0000269|PubMed:15322983, ECO:0000269|PubMed:17548557}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Myopathy, myosin storage, autosomal recessive (MSMB) [MIM:255160]: An autosomal recessive form of myosin storage myopathy, a muscle disease characterized by subsarcolemmal accumulation of hyalinized bodies in type 1 muscle fibers. MSMB clinical features include muscle weakness, type II respiratory failure and cardiac failure, due to hypertrophic cardiomyopathy. {ECO:0000269|PubMed:25666907}. Note=The disease is caused by mutations affecting the gene represented in this entry.; DISEASE: Left ventricular non-compaction 5 (LVNC5) [MIM:613426]: A form of left ventricular non-compaction, a cardiomyopathy due to myocardial morphogenesis arrest and characterized by a hypertrophic left ventricle, a severely thickened 2-layered myocardium, numerous prominent trabeculations, deep intertrabecular recesses, and poor systolic function. Clinical manifestations are variable. Some affected individuals experience no symptoms at all, others develop heart failure. In some cases, left ventricular non-compaction is associated with other congenital heart anomalies. LVNC5 is an autosomal dominant condition. {ECO:0000269|PubMed:18506004}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.;
- Pathway
- Cardiac muscle contraction - Homo sapiens (human);Dilated cardiomyopathy (DCM) - Homo sapiens (human);Viral myocarditis - Homo sapiens (human);Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human);Adrenergic signaling in cardiomyocytes - Homo sapiens (human);cGMP-PKG signaling pathway - Homo sapiens (human);Striated Muscle Contraction;Muscle contraction
(Consensus)
Recessive Scores
- pRec
- 0.168
Intolerance Scores
- loftool
- 0.0412
- rvis_EVS
- -3.64
- rvis_percentile_EVS
- 0.28
Haploinsufficiency Scores
- pHI
- 0.439
- hipred
- Y
- hipred_score
- 0.632
- ghis
- 0.561
Essentials
- essential_gene_CRISPR
- N
- essential_gene_CRISPR2
- N
- essential_gene_gene_trap
- N
- gene_indispensability_pred
- E
- gene_indispensability_score
- 0.895
Gene Damage Prediction
| All | Recessive | Dominant | |
|---|---|---|---|
| Mendelian | Medium | Medium | Medium |
| Primary Immunodeficiency | Medium | Medium | Medium |
| Cancer | Medium | Medium | Medium |
Mouse Genome Informatics
- Gene name
- Myh7
- Phenotype
- muscle phenotype; cardiovascular system phenotype (the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan);
Zebrafish Information Network
- Gene name
- myh7
- Affected structure
- cardiac ventricle
- Phenotype tag
- abnormal
- Phenotype quality
- curvature
Gene ontology
- Biological process
- regulation of the force of heart contraction;regulation of heart rate;skeletal muscle contraction;muscle contraction;striated muscle contraction;adult heart development;regulation of the force of skeletal muscle contraction;transition between fast and slow fiber;cardiac muscle hypertrophy in response to stress;muscle filament sliding;regulation of slow-twitch skeletal muscle fiber contraction;ATP metabolic process;ventricular cardiac muscle tissue morphogenesis;cardiac muscle contraction
- Cellular component
- stress fiber;muscle myosin complex;myosin complex;myofibril;sarcomere;Z disc;myosin filament
- Molecular function
- microfilament motor activity;protein binding;calmodulin binding;ATP binding;ATPase activity;actin-dependent ATPase activity;actin filament binding