NPY6R

neuropeptide Y receptor Y6 (pseudogene), the group of Neuropeptide Y receptors

Basic information

Region (hg38): 5:137808211-137809322

Links

ENSG00000226306

∙ NCBI:4888 ∙ OMIM:601770 ∙ HGNC:7959 ∙ Uniprot:Q99463 ∙ AlphaFold ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the NPY6R gene.

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the NPY6R gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding						0
Total	0	0	0	0	0

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP

Function: FUNCTION: When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function. {ECO:0000269|PubMed:8910290, ECO:0000269|PubMed:8910373}.;
Pathway: Peptide GPCRs;GPCRs, Class A Rhodopsin-like (Consensus)

Haploinsufficiency Scores

pHI: 0.650
hipred
hipred_score
ghis

Mouse Genome Informatics

Gene name: Npy6r
Phenotype: digestive/alimentary phenotype; behavior/neurological phenotype (the observable actions or reactions of mammalian organisms that are manifested through development and lifespan); liver/biliary system phenotype; homeostasis/metabolism phenotype; growth/size/body region phenotype; adipose tissue phenotype (the observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan);

Gene ontology

Biological process: G protein-coupled receptor signaling pathway;neuropeptide signaling pathway
Cellular component: integral component of membrane
Molecular function: pancreatic polypeptide receptor activity;neuropeptide Y receptor activity