PIP

protein-coding

prolactin induced protein

Gene summary

Enables IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of T cell apoptotic process; and proteolysis. Located in nucleus and obsolete extracellular space. [provided by Alliance of Genome Resources, Jun 2026]

MANE transcript

NM_002652.3

Inheritance

—

ClinVar variants

U:13B:7

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.86

Max pathogenic AF

—

Genomic locus

chr7:143,132,077-143,139,739

External References & Databases

Ensembl (ENSG00000159763)

Transcript & Mutation Effects

hg38 • Region Span ~7.7 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to PIP variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 14

not providedTotal: 4

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_002652.3. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous					2 clinvar	2
missense			11 clinvar	4 clinvar	1 clinvar	16
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)			2 clinvar			2
Total	0	0	13	4	3	20

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 4 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_002652.3	RefSeq	NP_002643.1	4	MANE Select
ENST00000291009.4	Ensembl	ENSP00000291009.3	4	MANE Select
ENST00001091657.1	Ensembl	ENSP00000761463.1	4	Standard
ENST00001134719.1	Ensembl	ENSP00000804803.1	4	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Pathways ConsensusPathDB

Transport of small molecules
Miscellaneous transport and binding events

Biological Process

detection of chemical stimulus involved in sensory perception of bitter taste
retina homeostasis
proteolysis
positive regulation of gene expression
transmembrane transport

Molecular Function

actin binding
aspartic-type endopeptidase activity
protein binding
IgG binding
protein dimerization activity

Cellular Component

extracellular region
extracellular space
nucleus
extracellular exosome

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000291009
Coding exons: 4
Length: 7670
Individuals with no LoFs: 125617
Homozygous LoFs: 3
Heterozygous LoFs: 116
Defined: 125736
p: 0.000473

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-0.189	89	84.1	1.06	0.00000478	952
Missense (PolyPhen)		27	26.802	1.0074		300
Synonymous	-0.0510	31	30.6	1.01	0.00000157	284
Loss of Function	0.318	5	5.83	0.858	3.45e-7	63

Population LoF Frequency

Population	CAF	p-value	Status
African	0	0.0	absent
Latino/Admixed American	0	0.0	absent
Ashkenazi Jewish	0	0.0	absent
East Asian	0.0014	0.0014	notable
Finnish	0.0020	0.0019	notable
European (Non-Finnish)	0.00033	0.00032	rare
South Asian	0.000066	0.000065	rare
Other	0.0024	0.0023	notable

dbNSFP Gene Annotations

Source: dbNSFP

Intolerance Scores

LoFtool: 0.666
RVIS EVS: 1.06
RVIS percentile EVS: 91.47

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.147

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium