RBM26

protein-coding

RNA binding motif protein 26, the group of RNA binding motif containing|Protein phosphatase 1 regulatory subunits|Zinc fingers CCCH-type

Gene summary

Enables RNA binding activity. Predicted to be involved in RNA catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

C13orf10

MANE transcript

NM_001366735.2

Inheritance

—

ClinVar variants

U:100B:5

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.04

Max pathogenic AF

—

Genomic locus

chr13:79,311,824-79,406,477

External References & Databases

Ensembl (ENSG00000139746)

Transcript & Mutation Effects

hg38 • Region Span ~94.7 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to RBM26 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 89

not providedTotal: 8

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001366735.2. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous			1 clinvar	2 clinvar		3
missense			91 clinvar	2 clinvar	1 clinvar	94
nonsense						0
start loss						0
frameshift			2 clinvar			2
splice donor/acceptor (+/-2bp)			6 clinvar			6
Total	0	0	100	4	1	105

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 102 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001366735.2	RefSeq	NP_001353664.1	22	MANE Select
ENST00000438737.3	Ensembl	ENSP00000387531.2	22	MANE Select
NM_001286631.2	RefSeq	NP_001273560.1	22	Standard
NM_001286632.2	RefSeq	NP_001273561.1	21	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

mRNA processing
negative regulation of phosphatase activity
positive regulation of RNA export from nucleus

Molecular Function

RNA binding
mRNA binding
protein binding
metal ion binding

Cellular Component

nucleus

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000267229
Coding exons: 21
Length: 94651
Individuals with no LoFs: 125739
Homozygous LoFs: 0
Heterozygous LoFs: 9
Defined: 125748
p: 0.0000358

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	2.53	358	520	0.688	0.0000266	6389
Missense (PolyPhen)		112	189.15	0.59211		2341
Synonymous	-0.561	183	174	1.05	0.00000829	1901
Loss of Function	6.71	2	56.3	0.0355	0.00000360	641

Population LoF Frequency

Population	CAF	p-value	Status
African	0	0.0	absent
Latino/Admixed American	0	0.0	absent
Ashkenazi Jewish	0	0.0	absent
East Asian	0	0.0	absent
Finnish	0	0.0	absent
European (Non-Finnish)	0.000028	0.000026	rare
South Asian	0.00018	0.00016	rare
Other	0.00021	0.00016	rare

dbNSFP Gene Annotations

Source: dbNSFP

Recessive Scores

pRec: 0.111

Intolerance Scores

LoFtool: 0.258
RVIS EVS: -1.42
RVIS percentile EVS: 4.1

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: E
Indispensability score: 0.944

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium