ROR1-AS1

ROR1 antisense RNA 1, the group of Antisense RNAs

Basic information

Region (hg38): 1:64094379-64171342

Links

ENSG00000223949 ∙ NCBI:101927034 ∙ ∙ HGNC:40508 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the ROR1-AS1 gene.

• not provided (34 variants)
• Inborn genetic diseases (7 variants)
• Hearing loss, autosomal recessive 108 (3 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the ROR1-AS1 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			20	13	8	41
Total	0	0	20	13	8

Variants in ROR1-AS1

This is a list of pathogenic ClinVar variants found in the ROR1-AS1 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
1-64137378-TGAA-T			Uncertain significance (Oct 03, 2023)
1-64137379-G-A			Uncertain significance (Apr 12, 2023)
1-64137385-G-T		not specified	Uncertain significance (Nov 15, 2021)
1-64137412-A-G			Uncertain significance (Nov 11, 2021)
1-64137431-T-C		not specified	Uncertain significance (Sep 17, 2021)
1-64137439-C-A			Uncertain significance (Oct 07, 2022)
1-64137455-A-G		not specified	Uncertain significance (Jun 27, 2023)
1-64137510-A-G			Likely benign (Dec 01, 2023)
1-64137512-G-T			Benign (Dec 12, 2023)
1-64137548-G-A			Benign (May 14, 2021)
1-64140113-C-G			Likely benign (Apr 13, 2023)
1-64140117-A-C			Uncertain significance (Aug 10, 2023)
1-64140128-C-T			Likely benign (Aug 15, 2022)
1-64140196-C-T		not specified	Uncertain significance (Jan 18, 2022)
1-64140200-C-T		ROR1-related disorder	Likely benign (Sep 21, 2023)
1-64140203-C-T			Likely benign (Aug 05, 2023)
1-64140246-G-A			Uncertain significance (May 16, 2023)
1-64140263-G-A			Likely benign (Jun 13, 2022)
1-64140312-A-G			Uncertain significance (Feb 13, 2023)
1-64140367-G-A		not specified	Uncertain significance (Jan 26, 2022)
1-64140379-C-T			Uncertain significance (Aug 16, 2022)
1-64140380-G-A			Likely benign (Nov 19, 2021)
1-64140382-A-G			Uncertain significance (Aug 02, 2023)
1-64142392-G-A			Likely benign (Oct 03, 2023)
1-64142398-T-C		ROR1-related disorder	Likely benign (Nov 24, 2020)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP