SENCR

smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA, the group of Long non-coding RNAs with non-systematic symbols

Basic information

Region (hg38): 11:128691664-128696038

Previous symbols: [ "FLI1-AS1" ]

Links

ENSG00000254703 ∙ NCBI:100507392 ∙ OMIM:615815 ∙ HGNC:44177 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the SENCR gene.

• not provided (18 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the SENCR gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			2	2	14	18
Total	0	0	2	2	14

Variants in SENCR

This is a list of pathogenic ClinVar variants found in the SENCR region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
11-128693881-TG-T			Benign (Jun 18, 2021)
11-128693941-CGAGA-C			Benign (Jun 20, 2021)
11-128693941-CGAGAGA-C			Benign (Jun 19, 2021)
11-128693941-CGAGAGAGA-C			Benign (Jun 19, 2021)
11-128693941-CGAGAGAGAGA-C			Benign (Jun 18, 2021)
11-128693941-CGAGAGAGAGAGAGAGAGA-C			Benign (Jun 19, 2021)
11-128694265-G-T			Uncertain significance (Aug 05, 2022)
11-128694270-T-C			Likely benign (Aug 30, 2017)
11-128694274-AAG-T			Uncertain significance (Mar 07, 2019)
11-128694284-G-A			Likely benign (May 10, 2023)
11-128694286-G-A			Likely benign (Apr 30, 2023)
11-128694294-G-A			Likely benign (Nov 26, 2022)
11-128694294-G-T			Likely benign (Dec 25, 2023)
11-128694478-AC-A			Benign (Jun 18, 2021)
11-128694497-GC-G			Benign (Jun 18, 2021)
11-128694511-GC-G			Benign (Jun 19, 2021)
11-128694517-GC-G			Benign (Jun 18, 2021)
11-128694542-CG-C			Benign (Jun 18, 2021)
11-128694581-CA-C			Benign (Jun 18, 2021)
11-128694587-A-G			Benign (Jun 18, 2021)
11-128694592-A-C			Benign (Jun 18, 2021)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP