SIGLEC10-AS1

SIGLEC10 antisense RNA 1, the group of Antisense RNAs

Basic information

Region (hg38): 19:51415724-51417425

Links

ENSG00000255441 ∙ NCBI:100129083 ∙ ∙ HGNC:40719 ∙ ∙ ∙ GenCC ∙ jax ∙ Sfari ∙ GnomAD ∙ Pubmed ∙ ClinVar

Phenotypes

GenCC

Source: genCC

No genCC data.

ClinVar

This is a list of variants' phenotypes submitted to ClinVar and linked to the SIGLEC10-AS1 gene.

• Inborn genetic diseases (12 variants)
• not provided (7 variants)

Variants pathogenicity by type

Statistics on ClinVar variants can assist in determining whether a specific variant type in the SIGLEC10-AS1 gene is commonly pathogenic or not.

In the table, we include only reliable ClinVar variants with their consequences to MANE Select, Mane Plus Clinical transcripts, or transcripts with TSL equals 1. Click the count to view the source variants.

Warning: slight differences between displayed counts and the number of variants in ClinVar may occur, primarily due to (1) the application of a different transcript and/or consequence by our variant effect predictor or (2) differences in clinical significance: we classify Benign/Likely benign variants as Likely benign and Pathogenic/Likely pathogenic variants as Likely pathogenic.

Variant type	Pathogenic	Likely pathogenic	VUS	Likely benign	Benign	Sum
synonymous						0
missense						0
nonsense						0
start loss						0
frameshift						0
inframe indel						0
splice donor/acceptor (+/-2bp)						0
splice region						0
non coding			11	4	4	19
Total	0	0	11	4	4

Variants in SIGLEC10-AS1

This is a list of pathogenic ClinVar variants found in the SIGLEC10-AS1 region.

You can filter this list by clicking the number of variants in the Variants pathogenicity by type table.

Position	Type	Phenotype	Significance	ClinVar
19-51415977-A-G			Likely benign (Feb 01, 2023)
19-51415978-G-T		not specified	Uncertain significance (Apr 20, 2024)
19-51415981-T-C			Likely benign (Feb 01, 2023)
19-51415983-C-T			Likely benign (Feb 01, 2023)
19-51416002-C-T		not specified	Likely benign (May 24, 2023)
19-51416008-G-A		not specified	Uncertain significance (Jan 31, 2024)
19-51416125-G-A		not specified	Likely benign (Sep 06, 2022)
19-51416149-T-G		not specified	Uncertain significance (May 10, 2024)
19-51416343-G-A		not specified	Uncertain significance (Nov 13, 2024)
19-51416684-C-A		not specified	Uncertain significance (Jun 16, 2023)
19-51416684-C-T		not specified	Uncertain significance (Oct 08, 2024)
19-51416686-G-C		not specified	Uncertain significance (May 30, 2024)
19-51416704-C-G		not specified	Uncertain significance (Dec 13, 2022)
19-51416744-T-C			Benign (Jul 26, 2018)
19-51416797-G-T		not specified	Uncertain significance (Dec 20, 2023)
19-51416811-G-A			Benign (May 15, 2018)
19-51416825-C-T		not specified	Likely benign (Jan 17, 2024)
19-51416846-G-T		not specified	Uncertain significance (Aug 28, 2024)
19-51416881-C-A		not specified	Uncertain significance (Dec 14, 2021)
19-51416906-G-A		not specified	Uncertain significance (Jul 14, 2021)
19-51416923-A-G		not specified	Uncertain significance (May 31, 2023)
19-51416956-A-G			Benign (Jul 16, 2018)
19-51417106-C-T		not specified	Likely benign (Mar 21, 2024)
19-51417235-A-G		not specified	Uncertain significance (Dec 17, 2021)
19-51417244-G-A		not specified	Uncertain significance (Mar 17, 2023)

GnomAD

Source: gnomAD

dbNSFP

Source: dbNSFP