SLC22A10

protein-coding

solute carrier family 22 member 10, the group of Solute carrier family 22

Gene summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

MANE transcript

NM_001039752.4

Inheritance

—

ClinVar variants

U:82B:5

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 1.12

Max pathogenic AF

—

Genomic locus

chr11:63,268,022-63,311,783

External References & Databases

Ensembl (ENSG00000184999)

Transcript & Mutation Effects

hg38 • Region Span ~43.8 kb

Loading mutation effect viewer...

GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to SLC22A10 variants in ClinVar

2 Conditions Cataloged

not specifiedTotal: 84

not providedTotal: 1

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001039752.4. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous				1 clinvar		1
missense			81 clinvar	4 clinvar		85
nonsense			1 clinvar			1
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	82	5	0	87

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 21 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001039752.4	RefSeq	NP_001034841.3	10	MANE Select
ENST00000332793.11	Ensembl	ENSP00000327569.6	10	MANE Select
ENST00000526800.1	Ensembl	ENSP00000433908.1	5	Standard
ENST00000526800.2	Ensembl	ENSP00000433908.2	5	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

transmembrane transport

Molecular Function

transmembrane transporter activity

Cellular Component

integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000332793
Coding exons: 10
Length: 231852
Individuals with no LoFs: 30557
Homozygous LoFs: 34513
Heterozygous LoFs: 60668
Defined: 125738
p: 0.507

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-0.835	339	298	1.14	0.0000154	3493
Missense (PolyPhen)		71	67.807	1.0471		862
Synonymous	-2.07	133	106	1.26	0.00000521	1124
Loss of Function	-0.546	27	24.1	1.12	0.00000132	268

Population LoF Frequency

Population	CAF	p-value	Status
African	0.29	0.30	notable
Latino/Admixed American	0.51	0.51	notable
Ashkenazi Jewish	0.45	0.45	notable
East Asian	0.42	0.42	notable
Finnish	0.61	0.60	notable
European (Non-Finnish)	0.58	0.57	notable
South Asian	0.45	0.44	notable
Other	0.53	0.53	notable

dbNSFP Gene Annotations

Source: dbNSFP

Intolerance Scores

LoFtool: 0.700
RVIS EVS: 1.85
RVIS percentile EVS: 97.12

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.0699

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	High	High	High
Primary Immunodeficiency	High	High	High
Cancer	High	High	High