SLC26A10P

pseudo

solute carrier family 26 member 10, pseudogene, the group of Solute carrier family 26

Gene summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport and sulfate transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

Previous symbols:

SLC26A10

MANE transcript

N/A

Inheritance

—

ClinVar variants

—

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 0.97

Max pathogenic AF

—

Genomic locus

chr12:57,619,527-57,626,036

External References & Databases

Ensembl (ENSG00000135502)

GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to SLC26A10P variants in ClinVar

2 Conditions Cataloged

not providedTotal: 3

not specifiedTotal: 2

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript . Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB
synonymous
missense
nonsense
start loss
frameshift
splice donor/acceptor (+/-2bp)
Total	0	0	0	0	0

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 0 of 0 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
No transcripts match your selected source or search query.

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Biological Process

bicarbonate transport
oxalate transport
sulfate transmembrane transport
chloride transmembrane transport

Molecular Function

secondary active sulfate transmembrane transporter activity
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
sulfate transmembrane transporter activity
anion:anion antiporter activity

Cellular Component

integral component of plasma membrane
basolateral plasma membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000320442
Coding exons: 14
Length: 6625
Individuals with no LoFs: 122400
Homozygous LoFs: 38
Heterozygous LoFs: 3310
Defined: 125748
p: 0.0134

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	0.208	291	301	0.966	0.0000154	3511
Missense (PolyPhen)		137	144.69	0.94688		1752
Synonymous	0.454	129	136	0.950	0.00000700	1249
Loss of Function	0.138	23	23.7	0.969	0.00000115	267

Population LoF Frequency

Population	CAF	p-value	Status
African	0.064	0.064	notable
Latino/Admixed American	0.013	0.013	notable
Ashkenazi Jewish	0.0048	0.0047	notable
East Asian	0.0022	0.0022	notable
Finnish	0.0058	0.0055	notable
European (Non-Finnish)	0.012	0.011	notable
South Asian	0.011	0.010	notable
Other	0.013	0.013	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Chloride/bicarbonate exchanger. {ECO:0000250}.;

Recessive Scores

pRec: 0.100

Intolerance Scores

LoFtool: 0.201
RVIS EVS: 2.22
RVIS percentile EVS: 98.16

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.351

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	High
Cancer	Medium	Medium	Medium