TAAR2

protein-coding

trace amine associated receptor 2, the group of Trace amine receptors

Gene summary

Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Previous symbols:

GPR58

MANE transcript

NM_001033080.1

Inheritance

—

ClinVar variants

U:57B:3

Top phenotype

—

gnomAD constraint

pLI —, LoF o/e 1.23

Max pathogenic AF

—

Genomic locus

chr6:132,617,022-132,624,275

External References & Databases

Ensembl (ENSG00000146378)

Transcript & Mutation Effects

hg38 • Region Span ~7.3 kb

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GenCC Phenotypes & Disease Associations

Curated gene-disease validity assertions and inheritance patterns

No GenCC data available for this gene.

ClinVar Associated Diseases & Phenotypes

Reported disease conditions connected to TAAR2 variants in ClinVar

1 Conditions Cataloged

not specifiedTotal: 60

ClinVar Variants & Pathogenicity by Type

Statistics based on transcript NM_001033080.1. Only rare variants are included.

We include only reliable ClinVar variants with their consequences to MANE Select, MANE Plus Clinical transcripts, or transcripts with TSL equal to 1. Click a count to filter the variants table below.

Slight differences between displayed counts and ClinVar may occur due to a different transcript/consequence chosen by our variant effect predictor, or because we classify Benign/Likely benign as Likely benign and Pathogenic/Likely pathogenic as Likely pathogenic.

Effect	PathogenicP	Likely pathogenicLP	VUS	Likely benignLB	BenignB	Sum
synonymous						0
missense			57 clinvar	3 clinvar		60
nonsense						0
start loss						0
frameshift						0
splice donor/acceptor (+/-2bp)						0
Total	0	0	57	3	0	60

Loading ClinVar variants...

Transcript Catalog

Annotated transcript isoforms across RefSeq and Ensembl databases

Showing 4 of 4 transcripts

Transcript ID	Source	Protein ID	Coding Exons	MANE Status
NM_001033080.1	RefSeq	NP_001028252.1	2	MANE Select
ENST00000367931.1	Ensembl	ENSP00000356908.1	2	MANE Select
NM_014626.3	RefSeq	NP_055441.2	1	Standard
ENST00000275191.2	Ensembl	ENSP00000275191.2	1	Standard

Gene Ontology (GO) Annotations & Pathways

Biological processes, molecular functions, cellular components and pathways

Pathways ConsensusPathDB

Neuroactive ligand-receptor interaction - Homo sapiens (human)
GPCRs, Other
Signaling by GPCR
Signal Transduction
G alpha (s) signalling events

Biological Process

G protein-coupled receptor signaling pathway

Molecular Function

trace-amine receptor activity
G protein-coupled receptor activity

Cellular Component

plasma membrane
integral component of membrane

gnomAD Constraint

Source: gnomAD

Gene type: protein_coding
Transcript type: protein_coding
Transcript: ENST00000367931
Coding exons: 2
Length: 7254
Individuals with no LoFs: 116765
Homozygous LoFs: 510
Heterozygous LoFs: 8413
Defined: 125688
p: 0.0362

	Z-Score	Observed	Expected	Observed/Expected	Mutation Rate	Total Possible
Missense	-0.236	193	184	1.05	0.00000835	2317
Missense (PolyPhen)		64	67.489	0.94831		895
Synonymous	-0.569	70	64.2	1.09	0.00000304	656
Loss of Function	-0.725	14	11.4	1.23	6.44e-7	154

Population LoF Frequency

Population	CAF	p-value	Status
African	0.025	0.025	notable
Latino/Admixed American	0.0088	0.0087	notable
Ashkenazi Jewish	0.015	0.015	notable
East Asian	0.20	0.19	notable
Finnish	0.016	0.016	notable
European (Non-Finnish)	0.023	0.023	notable
South Asian	0.060	0.059	notable
Other	0.033	0.032	notable

dbNSFP Gene Annotations

Source: dbNSFP

Function: FUNCTION: Orphan receptor.;

Recessive Scores

pRec: 0.0769

Intolerance Scores

LoFtool: 0.806
RVIS EVS: 0.2
RVIS percentile EVS: 67.19

Essentials

Essential (CRISPR): N
Essential (CRISPR2): N
Essential (gene trap): N
Indispensability pred.: N
Indispensability score: 0.123

Gene Damage Prediction

	All	Recessive	Dominant
Mendelian	Medium	Medium	Medium
Primary Immunodeficiency	Medium	Medium	Medium
Cancer	Medium	Medium	Medium